Homeostasis and self-tolerance within the immune system: turning lymphocytes off.
- There was an explosion in our data of the pathways and mechanisms by which the immune system can affect the mind and conduct.
- Within the context of irritation, pro-inflammatory cytokines can entry the central nervous system and work together with a cytokine community within the mind to affect nearly each facet of mind perform related to conduct together with neurotransmitter metabolism, neuroendocrine perform, synaptic plasticity, and neurocircuits that regulate temper, motor exercise, motivation, anxiousness and alarm.
Human T-Cell, Immune Regulator 1 (TCIRG1) ELISA Package
- Behavioral penalties of those results of the immune system on the mind embody despair, anxiousness, fatigue, psychomotor slowing, anorexia, cognitive dysfunction and sleep impairment; signs that overlap with these which characterize neuropsychiatric issues, particularly despair.
- Pathways that seem like particularly necessary in immune system results on the mind embody the cytokine signaling molecules, p38 mitogen-activated protein kinase and nuclear issue kappa B; indoleamine 2,three dioxygenase and its downstream metabolites, kynurenine, quinolinic acid and kynurenic acid; the neurotransmitters, serotonin, dopamine and glutamate; and neurocircuits involving the basal ganglia and anterior cingulate cortex.
- A sequence of vulnerability components together with ageing and weight problems in addition to persistent stress additionally seems to work together with proof against mind signaling to exacerbate immunologic contributions to neuropsychiatric illness.
- The elucidation of the mechanisms by which the immune system influences conduct yields a number of targets for potential therapeutic growth in addition to informing methods for the prevention of neuropsychiatric illness in in danger populations.
MUC16 CRISPR Knock Out Human OVCAR3-A1 Cell Line |
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T6230 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
Ccl2 CRISPR Knock Out CT26 Cell Line |
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T9611 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
CXCL8 CRISPR Knock Out L3.6pl Cell Line |
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T6220 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
CXCL1 CRISPR Knock Out L3.6pl Cell Line |
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T6221 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
SIRT CRISPR Knock Out Human HepG2 Cell Line - Clone T3-6 |
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T6804 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
PRSS21 CRISPR Knock Out Human OVCAR8 Cell Line - Clone T2 C8 |
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T6811 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
mAdrb2 CRISPR Knock Out B16 Cell Line (T1-10) |
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T9775 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
PTPN6 CRISPR Knock Out Human THP-1 Cell Line - Clone T3-1 |
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T6813 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
MSLN CRISPR Knock Out Human OVCAR3-A1 Cell Line - Clone T2 C4 |
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T6820 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
NUAK2 CRISPR Knock Out 293T Cell Line - Clone T3 #41 |
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T6801 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
NR2F6 CRISPR Knock Out Human Jurkat E6.1 Cell Line - Clone T3-10 |
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T6822 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
Aldh2 CRISPR Knock Out L929 Cell Line - Clone T3-20 |
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T9692 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
hPIM1 CRISPR Knock Out SACC-83 Cell Line-T3-9 |
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T9787 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
Dcx CRISPR Knock Out C6 Cell Line (Rat) - Clone sg4-1 |
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T9624 | ABM | 1x10^6 cells / 1.0 ml | EUR 3950 |
GLT1 CRISPR Knock Out Rat AST Cell Line - Clone T2-1 |
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T9678 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
PTPN11 CRISPR Knock Out NIH/3T3 Cell Line - Clone T4-9 |
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T6803 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
METTL3 CRISPR Knock Out Caki-1 Cell Line - Clone T2-16 |
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T9623 | ABM | 1x10^6 cells / 1.0 ml | EUR 3950 |
Nacc1 CRISPR Knock Out ID8 Cell Line (Mouse) - Clone T1-23 |
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T9627 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
osbpl2 CRISPR Knock Out NIH/3T3 Cell Line - T1 Polyclonal Pool |
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T9682 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
CARMIL1 CRISPR Knock Out Immortalized Human Gingival Fibroblast - hTERT Cell Line - T1-2 |
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T6825 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
Aifm1 CRISPR Knock Out Mouse L929 Cell Line - Clone T2-15-3 |
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T9674 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
SEC61G CRISPR Knock Out HCC-LM3 Cell Line - Clone T2-17-5 |
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T9746 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
Cell line gene knock-in and knock-out |
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S301 | 101Bio | - | EUR 15000 |
Tcirg1 3'UTR GFP Stable Cell Line |
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TU170294 | ABM | 1.0 ml | Ask for price |
Tcirg1 3'UTR GFP Stable Cell Line |
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TU271711 | ABM | 1.0 ml | Ask for price |
TCIRG1 3'UTR GFP Stable Cell Line |
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TU075334 | ABM | 1.0 ml | EUR 1672.8 |
TCIRG1 3'UTR Luciferase Stable Cell Line |
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TU025334 | ABM | 1.0 ml | EUR 1672.8 |
Tcirg1 3'UTR Luciferase Stable Cell Line |
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TU120294 | ABM | 1.0 ml | Ask for price |
Tcirg1 3'UTR Luciferase Stable Cell Line |
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TU221711 | ABM | 1.0 ml | Ask for price |
TCIRG1 sgRNA CRISPR Lentivector set (Human) |
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K2350501 | ABM | 3 x 1.0 ug | EUR 406.8 |
TCIRG1 sgRNA CRISPR Lentivector (Human) (Target 1) |
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K2350502 | ABM | 1.0 ug DNA | EUR 184.8 |
TCIRG1 sgRNA CRISPR Lentivector (Human) (Target 2) |
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K2350503 | ABM | 1.0 ug DNA | EUR 184.8 |
TCIRG1 sgRNA CRISPR Lentivector (Human) (Target 3) |
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K2350504 | ABM | 1.0 ug DNA | EUR 184.8 |
Araf CRISPR Knocked out RAW264.7 Stable cell Cell Line (Mouse) T3-3 |
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T9529 | ABM | 1x10^6 cells/1.0ml | EUR 3950 |
Araf CRISPR Knocked out RAW264.7 Stable cell Cell Line (Mouse) T1-19 |
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T9511 | ABM | 1x10^6 cells / 1.0 ml | EUR 3950 |
TCIRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human) |
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K2350505 | ABM | 3 x 1.0 ug | EUR 451.2 |
Tcirg1 sgRNA CRISPR Lentivector set (Rat) |
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K7409301 | ABM | 3 x 1.0 ug | EUR 406.8 |
Tcirg1 sgRNA CRISPR Lentivector set (Mouse) |
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K3161601 | ABM | 3 x 1.0 ug | EUR 406.8 |
Stable Mouse Myeloid-derived Suppressor-like LAL Knock Out (HD1B) Cell Line |
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T3187 | ABM | 1x10^6 cells / 1.0 ml | EUR 3950 |
TCIRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1) |
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K2350506 | ABM | 1.0 ug DNA | EUR 200.4 |
TCIRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2) |
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K2350507 | ABM | 1.0 ug DNA | EUR 200.4 |
TCIRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3) |
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K2350508 | ABM | 1.0 ug DNA | EUR 200.4 |
Tcirg1 sgRNA CRISPR Lentivector (Rat) (Target 1) |
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K7409302 | ABM | 1.0 ug DNA | EUR 184.8 |
Tcirg1 sgRNA CRISPR Lentivector (Rat) (Target 2) |
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K7409303 | ABM | 1.0 ug DNA | EUR 184.8 |
Tcirg1 sgRNA CRISPR Lentivector (Rat) (Target 3) |
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K7409304 | ABM | 1.0 ug DNA | EUR 184.8 |
Tcirg1 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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K3161602 | ABM | 1.0 ug DNA | EUR 184.8 |
Tcirg1 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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K3161603 | ABM | 1.0 ug DNA | EUR 184.8 |
Tcirg1 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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K3161604 | ABM | 1.0 ug DNA | EUR 184.8 |
Human MB knockout cell line |
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ABC-KH9065 | AcceGen | 1 vial | Ask for price |
Description: Human MB knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology. |
Human MB knockdown cell line |
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ABC-KD9065 | AcceGen | 1 vial | Ask for price |
Description: Human MB knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest. |
TCIRG1 siRNA (Human) |
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MBS8228581-15nmol | MyBiosource | 15nmol | EUR 405 |
TCIRG1 siRNA (Human) |
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MBS8228581-30nmol | MyBiosource | 30nmol | EUR 565 |
TCIRG1 siRNA (Human) |
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MBS8228581-5x30nmol | MyBiosource | 5x30nmol | EUR 2450 |
Human TCIRG1 ELISA KIT |
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EF003500 | Nova Lifetech | 96tests | EUR 566 |
Human TCIRG1 ELISA KIT |
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ELI-51415h | Nova Lifetech | 96tests | EUR 696 |
Human TCIRG1 shRNA Plasmid |
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20-abx956986 | Abbexa |
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Human TCIRG1 Protein Lysate |
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MBS8428363-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Tcirg1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat) |
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K7409305 | ABM | 3 x 1.0 ug | EUR 451.2 |
BRCA1 CRISPR Stable Knockout Human Fibroblast Cell Line |
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T6245 | ABM | 1x10^6 cells / 1.0 ml | EUR 3950 |
Tcirg1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse) |
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K3161605 | ABM | 3 x 1.0 ug | EUR 451.2 |
293AD Cell Line |
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AD-100 | Cell Biolabs | 1 vial | EUR 365 |
293AAV Cell Line |
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AAV-100 | Cell Biolabs | 1 vial | EUR 405 |
293LTV Cell Line |
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LTV-100 | Cell Biolabs | 1 vial | EUR 405 |
293RTV Cell Line |
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RV-100 | Cell Biolabs | 1 vial | EUR 405 |
Human T-Cell, Immune Regulator 1 (TCIRG1) Protein |
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20-abx655200 | Abbexa |
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Human T-Cell, Immune Regulator 1 (TCIRG1) Protein |
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abx655200-10g | Abbexa | 10 µg | EUR 200 |
Human T-Cell, Immune Regulator 1 (TCIRG1) Protein |
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abx655200-50g | Abbexa | 50 µg | EUR 337.5 |
Tcirg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1) |
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K7409306 | ABM | 1.0 ug DNA | EUR 200.4 |
Tcirg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2) |
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K7409307 | ABM | 1.0 ug DNA | EUR 200.4 |
Tcirg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3) |
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K7409308 | ABM | 1.0 ug DNA | EUR 200.4 |
TCIRG1 ORF Vector (Human) (pORF) |
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ORF010389 | ABM | 1.0 ug DNA | EUR 114 |
RNA silencing as a plant immune system towards viruses.
Malondialdehyde (MDA) Modified Human Albumin |
One in every of these methods is to provide proteins that concentrate on the cell autonomous or signalling steps of RNA silencing. It isn’t identified whether or not the same antiviral mechanism additionally operates in animal cells.
Does the immune system see tumors as international or self?
Paradoxically, whereas sturdy proof exists that particular immune surveillance techniques function at early phases of tumorigenesis, established tumors primarily induce immune tolerance.
OxiSelect TBARS Assay Package (MDA Quantitation) |
Description: The TBARS (Thiobarbituric Acid Reactive Substances) assay is well-established for screening and monitoring lipid peroxidation. MDA varieties a 1:2 adduct with thiobarbituric acid; the MDA-TBA adduct can then be measured. Our OxiSelect TBARS Assay Package supplies a way more user-friendly protocol to measure the MDA-TBA adduct.
Response volumes are a lot smaller than the normal assay, a lot much less pattern is required. Additionally, reactions will be carried out in normal polypropylene tubes – no glass tubes or glass marbles are required. Essential Word: MDA adducts aren’t steady long run. For finest outcomes check all samples instantly upon assortment, or freeze them at -80ºC for as much as one month. MDA could also be degraded in samples which were frozen for longer durations; in such instances extra dependable outcomes could also be obtained from extra steady markers of oxidative stress comparable to protein carbonyl, 8-OHdG or 4-HNE. |
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To elude immune surveillance, tumors should develop mechanisms that block the elaboration and sensing of proinflammatory hazard indicators, thereby shifting the steadiness from activation to tolerance induction. Elucidation of those mechanisms supplies new methods for most cancers immunotherapy.
AIRE 3'UTR Luciferase Stable Cell Line |
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TU000527 | ABM | 1.0 ml | EUR 1672.8 |
Aire 3'UTR Luciferase Stable Cell Line |
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TU101596 | ABM | 1.0 ml | Ask for price |
AIRN 3'UTR GFP Stable Cell Line |
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TU050528 | ABM | 1.0 ml | EUR 2799.6 |
A430089I19Rik 3'UTR GFP Stable Cell Line |
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TU151059 | ABM | 1.0 ml | Ask for price |
A430105I19Rik 3'UTR GFP Stable Cell Line |
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TU151060 | ABM | 1.0 ml | Ask for price |
A830093I24Rik 3'UTR GFP Stable Cell Line |
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TU151092 | ABM | 1.0 ml | Ask for price |
A930005I04Rik 3'UTR GFP Stable Cell Line |
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TU151094 | ABM | 1.0 ml | Ask for price |
40210 3'UTR GFP Stable Cell Line |
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TU057871 | ABM | 1.0 ml | EUR 2799.6 |
40211 3'UTR GFP Stable Cell Line |
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TU057872 | ABM | 1.0 ml | EUR 2799.6 |
40213 3'UTR GFP Stable Cell Line |
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TU057873 | ABM | 1.0 ml | EUR 2799.6 |
40214 3'UTR GFP Stable Cell Line |
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TU057874 | ABM | 1.0 ml | EUR 2799.6 |
40215 3'UTR GFP Stable Cell Line |
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TU057875 | ABM | 1.0 ml | EUR 2799.6 |
40216 3'UTR GFP Stable Cell Line |
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TU057876 | ABM | 1.0 ml | EUR 2799.6 |
40513 3'UTR GFP Stable Cell Line |
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TU055738 | ABM | 1.0 ml | EUR 2799.6 |
40238 3'UTR GFP Stable Cell Line |
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TU063013 | ABM | 1.0 ml | EUR 2799.6 |
40239 3'UTR GFP Stable Cell Line |
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TU063014 | ABM | 1.0 ml | EUR 2799.6 |
40240 3'UTR GFP Stable Cell Line |
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TU063015 | ABM | 1.0 ml | EUR 2799.6 |
40241 3'UTR GFP Stable Cell Line |
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TU063016 | ABM | 1.0 ml | EUR 2799.6 |
40242 3'UTR GFP Stable Cell Line |
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TU063017 | ABM | 1.0 ml | EUR 2799.6 |
40243 3'UTR GFP Stable Cell Line |
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TU063018 | ABM | 1.0 ml | EUR 2799.6 |
40244 3'UTR GFP Stable Cell Line |
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TU063019 | ABM | 1.0 ml | EUR 2799.6 |
40245 3'UTR GFP Stable Cell Line |
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TU063020 | ABM | 1.0 ml | EUR 2799.6 |
40246 3'UTR GFP Stable Cell Line |
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TU063021 | ABM | 1.0 ml | EUR 2799.6 |
40247 3'UTR GFP Stable Cell Line |
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TU063022 | ABM | 1.0 ml | EUR 2799.6 |
40248 3'UTR GFP Stable Cell Line |
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TU063023 | ABM | 1.0 ml | EUR 2799.6 |
40392 3'UTR GFP Stable Cell Line |
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TU064439 | ABM | 1.0 ml | EUR 2799.6 |
40391 3'UTR GFP Stable Cell Line |
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TU074935 | ABM | 1.0 ml | EUR 2799.6 |
40392 3'UTR GFP Stable Cell Line |
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TU074936 | ABM | 1.0 ml | EUR 2799.6 |
40393 3'UTR GFP Stable Cell Line |
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TU074937 | ABM | 1.0 ml | EUR 2799.6 |
40395 3'UTR GFP Stable Cell Line |
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TU074938 | ABM | 1.0 ml | EUR 2799.6 |
40391 3'UTR GFP Stable Cell Line |
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TU072603 | ABM | 1.0 ml | EUR 2799.6 |
40392 3'UTR GFP Stable Cell Line |
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TU072604 | ABM | 1.0 ml | EUR 2799.6 |
100041515 3'UTR GFP Stable Cell Line |
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TU150022 | ABM | 1.0 ml | Ask for price |
100043387 3'UTR GFP Stable Cell Line |
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TU150023 | ABM | 1.0 ml | Ask for price |
LIN9 3'UTR GFP Stable Cell Line |
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TU062483 | ABM | 1.0 ml | EUR 1672.8 |
Lin9 3'UTR GFP Stable Cell Line |
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TU257097 | ABM | 1.0 ml | Ask for price |
Lin9 3'UTR GFP Stable Cell Line |
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TU161077 | ABM | 1.0 ml | Ask for price |
LIN37 3'UTR GFP Stable Cell Line |
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TU062489 | ABM | 1.0 ml | EUR 1672.8 |
LIN52 3'UTR GFP Stable Cell Line |
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TU062490 | ABM | 1.0 ml | EUR 2799.6 |
LIN54 3'UTR GFP Stable Cell Line |
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TU062491 | ABM | 1.0 ml | EUR 2799.6 |
Lin37 3'UTR GFP Stable Cell Line |
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TU257091 | ABM | 1.0 ml | Ask for price |
Lin52 3'UTR GFP Stable Cell Line |
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TU257092 | ABM | 1.0 ml | Ask for price |
Lin54 3'UTR GFP Stable Cell Line |
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TU257093 | ABM | 1.0 ml | Ask for price |
Lin37 3'UTR GFP Stable Cell Line |
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TU161071 | ABM | 1.0 ml | Ask for price |
Lin52 3'UTR GFP Stable Cell Line |
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TU161072 | ABM | 1.0 ml | Ask for price |
Lin54 3'UTR GFP Stable Cell Line |
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TU161073 | ABM | 1.0 ml | Ask for price |
Stab1 3'UTR GFP Stable Cell Line |
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TU169791 | ABM | 1.0 ml | Ask for price |
Stab2 3'UTR GFP Stable Cell Line |
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TU169792 | ABM | 1.0 ml | Ask for price |
Stab2 3'UTR GFP Stable Cell Line |
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TU271257 | ABM | 1.0 ml | Ask for price |
STAB1 3'UTR GFP Stable Cell Line |
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TU074756 | ABM | 1.0 ml | EUR 1672.8 |
STAB2 3'UTR GFP Stable Cell Line |
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TU074757 | ABM | 1.0 ml | EUR 1672.8 |
P1 3'UTR GFP Stable Cell Line |
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TU067245 | ABM | 1.0 ml | EUR 2799.6 |
PC 3'UTR GFP Stable Cell Line |
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TU067459 | ABM | 1.0 ml | EUR 1672.8 |
PR@ 3'UTR GFP Stable Cell Line |
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TU068725 | ABM | 1.0 ml | EUR 1704 |
FH 3'UTR GFP Stable Cell Line |
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TU057963 | ABM | 1.0 ml | EUR 1672.8 |
GC 3'UTR GFP Stable Cell Line |
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TU058664 | ABM | 1.0 ml | EUR 1672.8 |
GK 3'UTR GFP Stable Cell Line |
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TU058836 | ABM | 1.0 ml | EUR 1825.2 |
CP 3'UTR GFP Stable Cell Line |
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TU054921 | ABM | 1.0 ml | EUR 1672.8 |
CS 3'UTR GFP Stable Cell Line |
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TU055079 | ABM | 1.0 ml | EUR 1672.8 |
KY 3'UTR GFP Stable Cell Line |
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TU062218 | ABM | 1.0 ml | EUR 1672.8 |
MB 3'UTR GFP Stable Cell Line |
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TU063059 | ABM | 1.0 ml | EUR 1672.8 |
MS 3'UTR GFP Stable Cell Line |
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TU064732 | ABM | 1.0 ml | EUR 2799.6 |
NA 3'UTR GFP Stable Cell Line |
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TU065157 | ABM | 1.0 ml | EUR 2799.6 |
NM 3'UTR GFP Stable Cell Line |
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TU065764 | ABM | 1.0 ml | EUR 2799.6 |
F2 3'UTR GFP Stable Cell Line |
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TU057158 | ABM | 1.0 ml | EUR 1672.8 |
F3 3'UTR GFP Stable Cell Line |
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TU057163 | ABM | 1.0 ml | EUR 1672.8 |
F5 3'UTR GFP Stable Cell Line |
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TU057164 | ABM | 1.0 ml | EUR 1672.8 |
F7 3'UTR GFP Stable Cell Line |
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TU057165 | ABM | 1.0 ml | EUR 1825.2 |
F8 3'UTR GFP Stable Cell Line |
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TU057167 | ABM | 1.0 ml | EUR 2799.6 |
F9 3'UTR GFP Stable Cell Line |
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TU057171 | ABM | 1.0 ml | EUR 1672.8 |
C2 3'UTR GFP Stable Cell Line |
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TU052161 | ABM | 1.0 ml | EUR 5540.4 |
C3 3'UTR GFP Stable Cell Line |
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TU052230 | ABM | 1.0 ml | EUR 1672.8 |
C5 3'UTR GFP Stable Cell Line |
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TU052331 | ABM | 1.0 ml | EUR 1672.8 |
C6 3'UTR GFP Stable Cell Line |
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TU052372 | ABM | 1.0 ml | EUR 1672.8 |
C7 3'UTR GFP Stable Cell Line |
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TU052459 | ABM | 1.0 ml | EUR 1672.8 |
C9 3'UTR GFP Stable Cell Line |
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TU052559 | ABM | 1.0 ml | EUR 1672.8 |
HP 3'UTR GFP Stable Cell Line |
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TU060116 | ABM | 1.0 ml | EUR 1672.8 |
HR 3'UTR GFP Stable Cell Line |
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TU060151 | ABM | 1.0 ml | EUR 1672.8 |
IK 3'UTR GFP Stable Cell Line |
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TU061004 | ABM | 1.0 ml | EUR 1672.8 |
IV 3'UTR GFP Stable Cell Line |
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TU061372 | ABM | 1.0 ml | EUR 2799.6 |
KL 3'UTR GFP Stable Cell Line |
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TU061818 | ABM | 1.0 ml | EUR 1825.2 |
AR 3'UTR GFP Stable Cell Line |
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TU051012 | ABM | 1.0 ml | EUR 5540.4 |