Th2 cells
th2cells

Suppressor cells as regulators of the immune system.

Posted on by Dominic

 

 

Myeloid-derived suppressor cells as regulators of the immune system.

 

 

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous inhabitants of cells that broaden throughout most cancers, irritation and an infection, and which have a exceptional skill to suppress T-cell responses. These cells represent a singular element of the immune system that regulates immune responses in wholesome people and within the context of varied ailments.
On this Evaluation, we focus on the origin, mechanisms of growth and suppressive features of MDSCs, in addition to the potential to focus on these cells for therapeutic profit.

From irritation to illness and despair: when the immune system subjugates the mind

 

In response to a peripheral an infection, innate immune cells produce pro-inflammatory cytokines that act on the mind to trigger illness behaviour. When activation of the peripheral immune system continues unabated, resembling throughout systemic infections, most cancers or autoimmune ailments, the following immune signalling to the mind can result in an exacerbation of illness and the event of signs of despair in susceptible people.

These phenomena would possibly account for the elevated prevalence of scientific despair in bodily in poor health folks. Irritation is due to this fact an vital organic occasion that may enhance the chance of main depressive episodes, very similar to the extra conventional psychosocial elements.

 

 

 

 

th2cells
th2cells

 

 

Perform and activation of NF-kappa B within the immunesystem.

 

NF-kappa B is a ubiquitous transcription issue. Nonetheless, its properties appear to be most extensively exploited in cells of the immune system. Amongst these properties are NF-kappa B’s fast posttranslational activation in response to many pathogenic alerts, its direct participation in cytoplasmic/nuclear signaling, and its efficiency to activate transcription of a terrific number of genes encoding immunologically related proteins.
In vertebrates, 5 distinct DNA binding subunits are at present identified which could extensively heterodimerize, thereby forming complexes with distinct transcriptional exercise, DNA sequence specificity, and cell type- and cell stage-specific distribution.

Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Antibody

The exercise of DNA binding NF-kappa B dimers is tightly managed by accent proteins known as I kappa B subunits of which there are additionally 5 completely different species at present identified in vertebrates. I kappa B proteins inhibit DNA binding and stop nuclear uptake of NF-kappa B complexes.

An exception is the Bcl-Three protein which as well as can operate as a transcription activating subunit in th nucleus. Different I kappa B proteins are quite concerned in terminating NF-kappa B’s exercise within the nucleus. The intracellular occasions that result in the inactivation of I kappa B, i.e. the activation of NF-kappa B, are complicated.
They contain phosphorylation and proteolytic reactions and appear to be managed by the cells’ redox standing. Interference with the activation or exercise of NF-kappa B could also be useful in suppressing poisonous/septic shock, graft-vs-host reactions, acute inflammatory reactions, acute part response, and radiation injury.
The inhibition of NF-kappa B activation by antioxidants and particular protease inhibitors might present a pharmacological foundation for interfering with these acute processes.

 

 

 

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Protein
20-abx653796
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) CLIA Kit
20-abx492710
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) CLIA Kit
20-abx492711
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
20-abx152058
  • EUR 8534.40
  • EUR 4550.40
  • EUR 1054.80
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
20-abx154266
  • EUR 8684.40
  • EUR 4626.00
  • EUR 1074.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
DLR-IREM1-Hu-48T 48T
EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
DLR-IREM1-Hu-96T 96T
EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
SEB377Hu-10x96wellstestplate 10x96-wells test plate
EUR 5402.92
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids.

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
SEB377Hu-1x48wellstestplate 1x48-wells test plate
EUR 550.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids.

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
SEB377Hu-1x96wellstestplate 1x96-wells test plate
EUR 734.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids.

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
SEB377Hu-5x96wellstestplate 5x96-wells test plate
EUR 2945.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids.

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
4-SEB377Hu
  • EUR 5463.60
  • EUR 2886.00
  • EUR 735.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
SEB377Mu-10x96wellstestplate 10x96-wells test plate
EUR 5552.14
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids.

Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
SEB377Mu-1x48wellstestplate 1x48-wells test plate
EUR 562.42
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids.

Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
SEB377Mu-1x96wellstestplate 1x96-wells test plate
EUR 752.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids.

Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
SEB377Mu-5x96wellstestplate 5x96-wells test plate
EUR 3024.07
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids.

Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
4-SEB377Mu
  • EUR 5612.40
  • EUR 2965.20
  • EUR 752.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in samples from Tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
RDR-IREM1-Hu-48Tests 48 Tests
EUR 626.4

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
RDR-IREM1-Hu-96Tests 96 Tests
EUR 868.8

Mouse Immune Receptor Expressed On Myeloid Cells 1 ELISA Kit (IREM1)
RK02956 96 Tests
EUR 625.2

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
RD-IREM1-Hu-48Tests 48 Tests
EUR 600

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
RD-IREM1-Hu-96Tests 96 Tests
EUR 830.4

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
RD-IREM1-Hu-48T 48T
EUR 432.3
Description: tissue homogenates, cell lysates and other biological fluids.

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
RD-IREM1-Hu-96T 96T
EUR 617.5
Description: tissue homogenates, cell lysates and other biological fluids.

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
RDR-IREM1-Hu-48T 48T
EUR 453.92
Description: tissue homogenates, cell lysates and other biological fluids.

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit
RDR-IREM1-Hu-96T 96T
EUR 648.38
Description: tissue homogenates, cell lysates and other biological fluids.

ELISA kit for Mouse IREM1 (Immune Receptor Expressed On Myeloid Cells 1)
ELK4999 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Immune Receptor Expressed On Myeloid Cells 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human IREM1 (Immune Receptor Expressed On Myeloid Cells 1)
ELK3899 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Immune Receptor Expressed On Myeloid Cells 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse)
4-PAB377Mu01
  • EUR 291.60
  • EUR 2948.40
  • EUR 735.60
  • EUR 366.00
  • EUR 254.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1)

Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), APC
4-PAB377Mu01-APC
  • EUR 408.00
  • EUR 3843.60
  • EUR 1072.80
  • EUR 518.40
  • EUR 260.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with APC.

Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), Cy3
4-PAB377Mu01-Cy3
  • EUR 493.20
  • EUR 5074.80
  • EUR 1381.20
  • EUR 642.00
  • EUR 297.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with Cy3.

Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), HRP
4-PAB377Mu01-HRP
  • EUR 373.20
  • EUR 3350.40
  • EUR 949.20
  • EUR 469.20
  • EUR 246.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with HRP.

Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), PE
4-PAB377Mu01-PE
  • EUR 350.40
  • EUR 3098.40
  • EUR 882.00
  • EUR 439.20
  • EUR 232.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with PE.

Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), FITC
4-PAB377Mu01-FITC
  • EUR 350.40
  • EUR 3098.40
  • EUR 882.00
  • EUR 439.20
  • EUR 232.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with FITC.

Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), Biotinylated
4-PAB377Mu01-Biotin
  • EUR 368.40
  • EUR 2888.40
  • EUR 856.80
  • EUR 450.00
  • EUR 260.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with Biotin.

Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), APC-Cy7
4-PAB377Mu01-APC-Cy7
  • EUR 672.00
  • EUR 7543.20
  • EUR 2002.80
  • EUR 894.00
  • EUR 378.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with APC-Cy7.

IREM-2
IREM2A-100T 100 test
EUR 652.8

IREM-2
IREM2AC750-100T 100 test
EUR 855.6

IREM-2
IREM2F-100T 100 test
EUR 512.4

IREM-2
IREM2PE-100T 100 test
EUR 621.6

IREM-2
IREM2PP-100T 100 test
EUR 684

IREM-2
IREM2PPC5.5-100T 100 test
EUR 684

IREM-2
IREM2PU-01MG 0,1 mg
EUR 356.4

IREM2 antibody (PE)
61R-1331 100 tests
EUR 625.2
Description: Mouse monoclonal IREM2 antibody (PE)

IREM-2 Antibody (FITC)
abx200514-100tests 100 tests
EUR 627.6

Mouse CMRF35-Like Molecule 2 / IREM-2 (CD300E) ELISA Kit
abx388809-96tests 96 tests
EUR 1093.2

Human CMRF35-Like Molecule 2 / IREM-2 (CD300E) ELISA Kit
abx384682-96tests 96 tests
EUR 1093.2

Mouse CMRF35-Like Molecule 7 / IREM-3 (CD300LB) ELISA Kit
abx254918-96tests 96 tests
EUR 886.8

Human CMRF35-Like Molecule 7 / IREM-3 (CD300LB) ELISA Kit
abx250732-96tests 96 tests
EUR 801.6

Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody
abx200513-100ug 100 ug
EUR 477.6

Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (PE)
abx200515-100tests 100 tests
EUR 727.2

Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (APC)
abx200516-100tests 100 tests
EUR 760.8

Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (PerCP)
abx200517-100tests 100 tests
EUR 777.6

Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (APC-C750)
abx200518-100tests 100 tests
EUR 1446

IRE1 Antibody
AF7650 200ul
EUR 540

IRE1 Antibody
AF7651 200ul
EUR 540

ERN1 (IRE1), GST-tag
40306 10 µg
EUR 410
Description: Human endoplasmic reticulumto-_x000D_nucleus signaling 1 (ERN1), also known as_x000D_inositol-requiring protein 1 (IRE1), GenBank_x000D_Accession No. NM_001433, a.a. 468-977_x000D_(end) MW = 87 kDa, expressed in a_x000D_baculovirus-infected Sf9 insect cell_x000D_expression system.

IRE1p Peptide
3655P 0.05 mg
EUR 197.7
Description: (CT) IRE1p peptide

IRE1p Peptide
3657P 0.05 mg
EUR 197.7
Description: (NT) IRE1p peptide

IRE1p Peptide
3659P 0.05 mg
EUR 197.7
Description: (IN) IRE1p peptide

IRE1 Antibody
45107-100ul 100ul
EUR 302.4

IRE1 Antibody
45107-50ul 50ul
EUR 224.4

IRE1 Antibody
ABD7709 100 ug
EUR 525.6

IRE1 Antibody
DF7709 200ul
EUR 420

IRE1 Antibody
RQ4356 100 ug
EUR 356.15
Description: The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1 or IRE1a) is an enzyme that in humans is encoded by the ERN1 gene. This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.

IRE1 Antibody
R35073-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Inositol-requiring 1, endoplasmic reticulum to nucleus signaling 1, ERN1

IRE1p Antibody
24369-100ul 100ul
EUR 468

IRE1p Antibody
24370-100ul 100ul
EUR 468

IRE1p Antibody
24371-100ul 100ul
EUR 468

Human IRE1, His-tag
40709 10 µg
EUR 355
Description: Human serine/threonineprotein_x000D_kinase/endoribonuclease IRE1_x000D_(IRE1), a.a. 469-977 with a N-terminal_x000D_His-tag, TEV sequence, and AviTag™._x000D_MW = 62 kDa, expressed in_x000D_baculovirus-infected Sf9 insect cell_x000D_expression system.

IRE1p Antibody
3655-002mg 0.02 mg
EUR 206.18
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

IRE1p Antibody
3655-01mg 0.1 mg
EUR 523.7
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

IRE1p Antibody
3657-002mg 0.02 mg
EUR 206.18
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

IRE1p Antibody
3657-01mg 0.1 mg
EUR 523.7
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

IRE1p Antibody
3659-002mg 0.02 mg
EUR 206.18
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

IRE1p Antibody
3659-01mg 0.1 mg
EUR 523.7
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

IRE2 Antibody / ERN2
RQ6864 100ug
EUR 356.15
Description: IRE2/ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of IRE2/ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

IREB2/ Rat IREB2 ELISA Kit
ELA-E13568r 96 Tests
EUR 1063.2

Ireb2/ Rat Ireb2 ELISA Kit
ELI-31084r 96 Tests
EUR 1063.2

IRE1 Antibody (pS724)
RQ4781 100ul
EUR 356.15
Description: IRE1 is a serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the ER luminal domain is maintained in its inactive monomeric state by binding to the ER chaperone HSPA5/BiP. Accumulation of misfolded protein in the ER causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity. [UniProt]

IRE1 Blocking Peptide
AF7650-BP 1mg
EUR 234

 

Complement: a key system for immune surveillance and homeostasis.

 

Almost a century after the importance of the human complement system was acknowledged, we have now come to understand that its features prolong far past the elimination of microbes. Complement acts as a fast and environment friendly immune surveillance system that has distinct results on wholesome and altered host cells and overseas intruders.

Recombinant Immune Receptor Expressed On Myeloid Cells 1 (IREM1)
By eliminating mobile particles and infectious microbes, orchestrating immune responses and sending ‘hazard’ alerts, complement contributes considerably to homeostasis, however it could actually additionally take motion towards wholesome cells if not correctly managed.
This overview describes our up to date view of the operate, construction and dynamics of the complement community, highlights its interconnection with immunity at giant and with different endogenous pathways, and illustrates its a number of roles in homeostasis and illness.

Regulation and performance of NF-kappaB transcription elements within the immune system.

 

 

The mammalian Rel/NF-kappaB household of transcription elements, together with RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), performs a central function within the immune system by regulating a number of processes starting from the event and survival of lymphocytes and lymphoid organs to the management of immune responses and malignant transformation.
The 5 members of the NF-kappaB household are usually saved inactive within the cytoplasm by interplay with inhibitors known as IkappaBs or the unprocessed types of NF-kappaB1 and NF-kappaB2. All kinds of alerts emanating from antigen receptors, pattern-recognition receptors, receptors for the members of TNF and IL-1 cytokine households, and others induce differential activation of NF-kappaB heterodimers.

AIRE Polyclonal Antibody
  • Conjugation: Unconjugated
  • Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
  • Purified by: Affinity purification
  • Background: This gene encodes a transcriptional regulator that kinds nuclear our bodies and interacts
Though work over the previous 20 years has shed vital mild on the regulation of NF-kappaB transcription elements and their features, a lot progress has been made up to now two years revealing new insights into the regulation and features of NF-kappaB. This latest progress is roofed on this overview.

 

 

AIRE antibody
70R-33714 100 ug
EUR 392.4
Description: Rabbit polyclonal AIRE antibody

AIRE antibody
70R-51449 100 ul
EUR 292.8
Description: Purified Polyclonal AIRE antibody

AIRE antibody
70R-34455 100 ug
EUR 392.4
Description: Rabbit polyclonal AIRE antibody

AIRE Antibody
33590-100ul 100ul
EUR 302.4

AIRE Antibody
33590-50ul 50ul
EUR 224.4

AIRE Antibody
32424-100ul 100ul
EUR 302.4

AIRE Antibody
ABD3026 100 ug
EUR 525.6

AIRE Antibody
ABF0334 100 ug
EUR 525.6

AIRE Antibody
ABF5471 100 ug
EUR 525.6

AIRE Antibody
ABD6603 100 ug
EUR 525.6

AIRE Antibody
1-CSB-PA009261
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

AIRE Antibody
DF6603 200ul
EUR 420

AIRE Antibody
DF3026 200ul
EUR 420

AIRE Antibody
CSB-PA274868- each
EUR 402
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

AIRE Antibody
CSB-PA274868-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

AIRE Antibody
1-CSB-PA000839
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/10000

AIRE Antibody
1-CSB-PA001502HA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

AIRE Antibody
CSB-PA001502KA01HU- each
EUR 402
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

AIRE Antibody
CSB-PA001502KA01HU-100ul 100ul
EUR 466.8
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

AIRE Antibody
R35463-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Autoimmune regulator, APECED, Automimmune polyendocrinopathy candidiasis ectodermal dystrophy

AIRE Antibody
R34350-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Autoimmune regulator protein

AIRE Antibody
R34389-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), APECED

AIRE Antibody
R32465 100 ug
EUR 356.15
Description: The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

AIRE Rabbit pAb
A14183-100ul 100 ul
EUR 369.6

AIRE Rabbit pAb
A14183-200ul 200 ul
EUR 550.8

AIRE Rabbit pAb
A14183-20ul 20 ul
EUR 219.6

AIRE Rabbit pAb
A14183-50ul 50 ul
EUR 267.6

AIRE Rabbit pAb
A1767-100ul 100 ul
EUR 369.6

AIRE Rabbit pAb
A1767-200ul 200 ul
EUR 550.8

AIRE Rabbit pAb
A1767-20ul 20 ul
EUR 219.6

AIRE Rabbit pAb
A1767-50ul 50 ul
EUR 267.6

AIRE (isoform 1)
GT41000 100 ug
EUR 568.8

anti- AIRE antibody
FNab00241 100µg
EUR 606.3
Description: Antibody raised against AIRE

AIRE (pS156) Antibody
abx332932-100ul 100 ul
EUR 560.4

AIRE antibody (Ser156)
70R-34454 100 ug
EUR 392.4
Description: Rabbit polyclonal AIRE antibody (Ser156)

AIRE Blocking Peptide
20-abx062024
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

AIRE Blocking Peptide
AF0334-BP 1mg
EUR 234

AIRE Blocking Peptide
DF6603-BP 1mg
EUR 234

AIRE Blocking Peptide
DF3026-BP 1mg
EUR 234

Polyclonal AIRE Antibody
APR03336G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AIRE . This antibody is tested and proven to work in the following applications:

AIRE Conjugated Antibody
C32424 100ul
EUR 476.4

AIRE-1 Polyclonal Antibody
40562-100ul 100ul
EUR 302.4

AIRE-1 Polyclonal Antibody
40562-50ul 50ul
EUR 224.4

AIRE-1 Polyclonal Antibody
ABP50619-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AIRE-1 from Human, Mouse. This AIRE-1 antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AIRE-1 at AA range: 60-140

AIRE-1 Polyclonal Antibody
ABP50619-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AIRE-1 from Human, Mouse. This AIRE-1 antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AIRE-1 at AA range: 60-140

AIRE-1 Polyclonal Antibody
ABP50619-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AIRE-1 from Human, Mouse. This AIRE-1 antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AIRE-1 at AA range: 60-140

AIRE-1 Polyclonal Antibody
ABP54773-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AIRE-1 from Human. This AIRE-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156

AIRE-1 Polyclonal Antibody
ABP54773-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AIRE-1 from Human. This AIRE-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156

AIRE-1 Polyclonal Antibody
ABP54773-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AIRE-1 from Human. This AIRE-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156

AIRE-1 Polyclonal Antibody
ES1618-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

AIRE-1 Polyclonal Antibody
ES1618-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

AIRE-1 Polyclonal Antibody
ES5772-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

AIRE-1 Polyclonal Antibody
ES5772-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Rat AIRE ELISA Kit
ERA0534 96Tests
EUR 625.2

AIRE Cell ELISA Kit
abx595022-96tests 96 tests
EUR 764.4

Goat AIRE ELISA Kit
EGTA0534 96Tests
EUR 625.2

Mouse AIRE ELISA Kit
EMA0534 96Tests
EUR 625.2

Sheep AIRE ELISA Kit
ESA0534 96Tests
EUR 625.2

Human AIRE ELISA Kit
ELA-E13302h 96 Tests
EUR 988.8

AIRE ELISA KIT|Human
EF005361 96 Tests
EUR 826.8

Human AIRE ELISA Kit
EHA0534 96Tests
EUR 625.2

Monkey AIRE ELISA Kit
EMKA0534 96Tests
EUR 625.2

Rabbit AIRE ELISA Kit
ERTA0534 96Tests
EUR 625.2

Bovine AIRE ELISA Kit
EBA0534 96Tests
EUR 625.2

Canine AIRE ELISA Kit
ECA0534 96Tests
EUR 625.2

Porcine AIRE ELISA Kit
EPA0534 96Tests
EUR 625.2

Chicken AIRE ELISA Kit
ECKA0534 96Tests
EUR 625.2

Anserini AIRE ELISA Kit
EAA0534 96Tests
EUR 625.2

Human AIRE shRNA Plasmid
20-abx950227
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse AIRE shRNA Plasmid
20-abx969093
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

AIRE (Isoform 1) Antibody
abx432298-200ul 200 ul
EUR 460.8

AIRE Antibody, HRP conjugated
1-CSB-PA001502HB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

AIRE Recombinant Protein (Rat)
RP189656 100 ug Ask for price

AIRE Antibody, FITC conjugated
1-CSB-PA001502HC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

AIRE (Phospho-Ser156) Antibody
11782-100ul 100ul
EUR 302.4

AIRE (Phospho-Ser156) Antibody
11782-50ul 50ul
EUR 224.4

AIRE Recombinant Protein (Mouse)
RP115070 100 ug Ask for price

AIRE Recombinant Protein (Human)
RP046219 100 ug Ask for price

AIRE Antibody, Biotin conjugated
1-CSB-PA001502HD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

AIRE-1 Polyclonal Conjugated Antibody
C40562 100ul
EUR 476.4

Aire ORF Vector (Rat) (pORF)
ORF063220 1.0 ug DNA
EUR 607.2

Polyclonal AIRE Antibody (Internal)
APG00998G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human AIRE (Internal). This antibody is tested and proven to work in the following applications:

Guinea Pig AIRE ELISA Kit
EGA0534 96Tests
EUR 625.2

Autoimmune Regulator (AIRE) Antibody
20-abx312575
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Autoimmune Regulator (AIRE) Antibody
abx230241-100ug 100 ug
EUR 577.2

Autoimmune Regulator (AIRE) Antibody
20-abx175527
  • EUR 1446.00
  • EUR 693.60
  • 1 mg
  • 200 ug

Autoimmune Regulator (AIRE) Antibody
20-abx175528
  • EUR 1479.60
  • EUR 710.40
  • 1 mg
  • 200 ug

Autoimmune Regulator (AIRE) Antibody
20-abx175529
  • EUR 1479.60
  • EUR 710.40
  • 1 mg
  • 200 ug

Leave a Reply

Your email address will not be published.