Myeloid-derived suppressor cells as regulators of the immune system.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous inhabitants of cells that broaden throughout most cancers, irritation and an infection, and which have a exceptional skill to suppress T-cell responses. These cells represent a singular element of the immune system that regulates immune responses in wholesome people and within the context of varied ailments.
On this Evaluation, we focus on the origin, mechanisms of growth and suppressive features of MDSCs, in addition to the potential to focus on these cells for therapeutic profit.
From irritation to illness and despair: when the immune system subjugates the mind
In response to a peripheral an infection, innate immune cells produce pro-inflammatory cytokines that act on the mind to trigger illness behaviour. When activation of the peripheral immune system continues unabated, resembling throughout systemic infections, most cancers or autoimmune ailments, the following immune signalling to the mind can result in an exacerbation of illness and the event of signs of despair in susceptible people.
These phenomena would possibly account for the elevated prevalence of scientific despair in bodily in poor health folks. Irritation is due to this fact an vital organic occasion that may enhance the chance of main depressive episodes, very similar to the extra conventional psychosocial elements.

Perform and activation of NF-kappa B within the immunesystem.
NF-kappa B is a ubiquitous transcription issue. Nonetheless, its properties appear to be most extensively exploited in cells of the immune system. Amongst these properties are NF-kappa B’s fast posttranslational activation in response to many pathogenic alerts, its direct participation in cytoplasmic/nuclear signaling, and its efficiency to activate transcription of a terrific number of genes encoding immunologically related proteins.
In vertebrates, 5 distinct DNA binding subunits are at present identified which could extensively heterodimerize, thereby forming complexes with distinct transcriptional exercise, DNA sequence specificity, and cell type- and cell stage-specific distribution.
Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Antibody |
The exercise of DNA binding NF-kappa B dimers is tightly managed by accent proteins known as I kappa B subunits of which there are additionally 5 completely different species at present identified in vertebrates. I kappa B proteins inhibit DNA binding and stop nuclear uptake of NF-kappa B complexes.
An exception is the Bcl-Three protein which as well as can operate as a transcription activating subunit in th nucleus. Different I kappa B proteins are quite concerned in terminating NF-kappa B’s exercise within the nucleus. The intracellular occasions that result in the inactivation of I kappa B, i.e. the activation of NF-kappa B, are complicated.
They contain phosphorylation and proteolytic reactions and appear to be managed by the cells’ redox standing. Interference with the activation or exercise of NF-kappa B could also be useful in suppressing poisonous/septic shock, graft-vs-host reactions, acute inflammatory reactions, acute part response, and radiation injury.
The inhibition of NF-kappa B activation by antioxidants and particular protease inhibitors might present a pharmacological foundation for interfering with these acute processes.
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Protein |
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20-abx653796 | Abbexa |
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Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) CLIA Kit |
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20-abx492710 | Abbexa |
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Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) CLIA Kit |
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20-abx492711 | Abbexa |
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Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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20-abx152058 | Abbexa |
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Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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20-abx154266 | Abbexa |
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Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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DLR-IREM1-Hu-48T | DL Develop | 48T | EUR 597.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in samples from tissue homogenates, cell lysates or other biological fluids. |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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DLR-IREM1-Hu-96T | DL Develop | 96T | EUR 776.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in samples from tissue homogenates, cell lysates or other biological fluids. |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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SEB377Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5402.92 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids. |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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SEB377Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 550.13 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids. |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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SEB377Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 734.46 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids. |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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SEB377Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2945.08 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids. |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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4-SEB377Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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SEB377Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5552.14 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids. |
Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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SEB377Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 562.42 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids. |
Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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SEB377Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 752.02 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids. |
Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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SEB377Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3024.07 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in Tissue homogenates, cell lysates and other biological fluids. |
Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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4-SEB377Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) in samples from Tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species. |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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RDR-IREM1-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 626.4 |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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RDR-IREM1-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 868.8 |
Mouse Immune Receptor Expressed On Myeloid Cells 1 ELISA Kit (IREM1) |
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RK02956 | Abclonal | 96 Tests | EUR 625.2 |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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RD-IREM1-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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RD-IREM1-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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RD-IREM1-Hu-48T | Reddot Biotech | 48T | EUR 432.3 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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RD-IREM1-Hu-96T | Reddot Biotech | 96T | EUR 617.5 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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RDR-IREM1-Hu-48T | Reddot Biotech | 48T | EUR 453.92 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) ELISA Kit |
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RDR-IREM1-Hu-96T | Reddot Biotech | 96T | EUR 648.38 |
Description: tissue homogenates, cell lysates and other biological fluids. |
ELISA kit for Mouse IREM1 (Immune Receptor Expressed On Myeloid Cells 1) |
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ELK4999 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
Description: A sandwich ELISA kit for detection of Immune Receptor Expressed On Myeloid Cells 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
ELISA kit for Human IREM1 (Immune Receptor Expressed On Myeloid Cells 1) |
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ELK3899 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
Description: A sandwich ELISA kit for detection of Immune Receptor Expressed On Myeloid Cells 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse) |
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4-PAB377Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1) |
Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), APC |
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4-PAB377Mu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with APC. |
Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), Cy3 |
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4-PAB377Mu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with Cy3. |
Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), HRP |
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4-PAB377Mu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with HRP. |
Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), PE |
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4-PAB377Mu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with PE. |
Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), FITC |
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4-PAB377Mu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with FITC. |
Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), Biotinylated |
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4-PAB377Mu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with Biotin. |
Immune Receptor Expressed On Myeloid Cells 1 (IREM1) Polyclonal Antibody (Human, Mouse), APC-Cy7 |
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4-PAB377Mu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Immune Receptor Expressed On Myeloid Cells 1 (IREM1). This antibody is labeled with APC-Cy7. |
IREM-2 |
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IREM2A-100T | ImmunoStep | 100 test | EUR 652.8 |
IREM-2 |
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IREM2AC750-100T | ImmunoStep | 100 test | EUR 855.6 |
IREM-2 |
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IREM2F-100T | ImmunoStep | 100 test | EUR 512.4 |
IREM-2 |
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IREM2PE-100T | ImmunoStep | 100 test | EUR 621.6 |
IREM-2 |
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IREM2PP-100T | ImmunoStep | 100 test | EUR 684 |
IREM-2 |
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IREM2PPC5.5-100T | ImmunoStep | 100 test | EUR 684 |
IREM-2 |
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IREM2PU-01MG | ImmunoStep | 0,1 mg | EUR 356.4 |
IREM2 antibody (PE) |
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61R-1331 | Fitzgerald | 100 tests | EUR 625.2 |
Description: Mouse monoclonal IREM2 antibody (PE) |
IREM-2 Antibody (FITC) |
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abx200514-100tests | Abbexa | 100 tests | EUR 627.6 |
Mouse CMRF35-Like Molecule 2 / IREM-2 (CD300E) ELISA Kit |
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abx388809-96tests | Abbexa | 96 tests | EUR 1093.2 |
Human CMRF35-Like Molecule 2 / IREM-2 (CD300E) ELISA Kit |
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abx384682-96tests | Abbexa | 96 tests | EUR 1093.2 |
Mouse CMRF35-Like Molecule 7 / IREM-3 (CD300LB) ELISA Kit |
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abx254918-96tests | Abbexa | 96 tests | EUR 886.8 |
Human CMRF35-Like Molecule 7 / IREM-3 (CD300LB) ELISA Kit |
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abx250732-96tests | Abbexa | 96 tests | EUR 801.6 |
Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody |
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abx200513-100ug | Abbexa | 100 ug | EUR 477.6 |
Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (PE) |
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abx200515-100tests | Abbexa | 100 tests | EUR 727.2 |
Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (APC) |
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abx200516-100tests | Abbexa | 100 tests | EUR 760.8 |
Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (PerCP) |
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abx200517-100tests | Abbexa | 100 tests | EUR 777.6 |
Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (APC-C750) |
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abx200518-100tests | Abbexa | 100 tests | EUR 1446 |
IRE1 Antibody |
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AF7650 | Affbiotech | 200ul | EUR 540 |
IRE1 Antibody |
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AF7651 | Affbiotech | 200ul | EUR 540 |
ERN1 (IRE1), GST-tag |
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40306 | BPS Bioscience | 10 µg | EUR 410 |
Description: Human endoplasmic reticulumto-_x000D_nucleus signaling 1 (ERN1), also known as_x000D_inositol-requiring protein 1 (IRE1), GenBank_x000D_Accession No. NM_001433, a.a. 468-977_x000D_(end) MW = 87 kDa, expressed in a_x000D_baculovirus-infected Sf9 insect cell_x000D_expression system. |
IRE1p Peptide |
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3655P | ProSci | 0.05 mg | EUR 197.7 |
Description: (CT) IRE1p peptide |
IRE1p Peptide |
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3657P | ProSci | 0.05 mg | EUR 197.7 |
Description: (NT) IRE1p peptide |
IRE1p Peptide |
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3659P | ProSci | 0.05 mg | EUR 197.7 |
Description: (IN) IRE1p peptide |
IRE1 Antibody |
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45107-100ul | SAB | 100ul | EUR 302.4 |
IRE1 Antibody |
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45107-50ul | SAB | 50ul | EUR 224.4 |
IRE1 Antibody |
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ABD7709 | Lifescience Market | 100 ug | EUR 525.6 |
IRE1 Antibody |
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DF7709 | Affbiotech | 200ul | EUR 420 |
IRE1 Antibody |
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RQ4356 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1 or IRE1a) is an enzyme that in humans is encoded by the ERN1 gene. This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. |
IRE1 Antibody |
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R35073-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Inositol-requiring 1, endoplasmic reticulum to nucleus signaling 1, ERN1 |
IRE1p Antibody |
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24369-100ul | SAB | 100ul | EUR 468 |
IRE1p Antibody |
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24370-100ul | SAB | 100ul | EUR 468 |
IRE1p Antibody |
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24371-100ul | SAB | 100ul | EUR 468 |
Human IRE1, His-tag |
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40709 | BPS Bioscience | 10 µg | EUR 355 |
Description: Human serine/threonineprotein_x000D_kinase/endoribonuclease IRE1_x000D_(IRE1), a.a. 469-977 with a N-terminal_x000D_His-tag, TEV sequence, and AviTag™._x000D_MW = 62 kDa, expressed in_x000D_baculovirus-infected Sf9 insect cell_x000D_expression system. |
IRE1p Antibody |
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3655-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
IRE1p Antibody |
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3655-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
IRE1p Antibody |
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3657-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
IRE1p Antibody |
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3657-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
IRE1p Antibody |
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3659-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
IRE1p Antibody |
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3659-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: IRE1p Antibody: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
IRE2 Antibody / ERN2 |
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RQ6864 | NSJ Bioreagents | 100ug | EUR 356.15 |
Description: IRE2/ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of IRE2/ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells. |
IREB2/ Rat IREB2 ELISA Kit |
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ELA-E13568r | Lifescience Market | 96 Tests | EUR 1063.2 |
Ireb2/ Rat Ireb2 ELISA Kit |
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ELI-31084r | Lifescience Market | 96 Tests | EUR 1063.2 |
IRE1 Antibody (pS724) |
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RQ4781 | NSJ Bioreagents | 100ul | EUR 356.15 |
Description: IRE1 is a serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the ER luminal domain is maintained in its inactive monomeric state by binding to the ER chaperone HSPA5/BiP. Accumulation of misfolded protein in the ER causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity. [UniProt] |
IRE1 Blocking Peptide |
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AF7650-BP | Affbiotech | 1mg | EUR 234 |
Complement: a key system for immune surveillance and homeostasis.
Almost a century after the importance of the human complement system was acknowledged, we have now come to understand that its features prolong far past the elimination of microbes. Complement acts as a fast and environment friendly immune surveillance system that has distinct results on wholesome and altered host cells and overseas intruders.
Recombinant Immune Receptor Expressed On Myeloid Cells 1 (IREM1) |
By eliminating mobile particles and infectious microbes, orchestrating immune responses and sending ‘hazard’ alerts, complement contributes considerably to homeostasis, however it could actually additionally take motion towards wholesome cells if not correctly managed.
This overview describes our up to date view of the operate, construction and dynamics of the complement community, highlights its interconnection with immunity at giant and with different endogenous pathways, and illustrates its a number of roles in homeostasis and illness.
Regulation and performance of NF-kappaB transcription elements within the immune system.
The mammalian Rel/NF-kappaB household of transcription elements, together with RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), performs a central function within the immune system by regulating a number of processes starting from the event and survival of lymphocytes and lymphoid organs to the management of immune responses and malignant transformation.
The 5 members of the NF-kappaB household are usually saved inactive within the cytoplasm by interplay with inhibitors known as IkappaBs or the unprocessed types of NF-kappaB1 and NF-kappaB2. All kinds of alerts emanating from antigen receptors, pattern-recognition receptors, receptors for the members of TNF and IL-1 cytokine households, and others induce differential activation of NF-kappaB heterodimers.
AIRE Polyclonal Antibody |
- Conjugation: Unconjugated
- Buffer composition: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
- Purified by: Affinity purification
- Background: This gene encodes a transcriptional regulator that kinds nuclear our bodies and interacts
Though work over the previous 20 years has shed vital mild on the regulation of NF-kappaB transcription elements and their features, a lot progress has been made up to now two years revealing new insights into the regulation and features of NF-kappaB. This latest progress is roofed on this overview.
AIRE antibody |
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70R-33714 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal AIRE antibody |
AIRE antibody |
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70R-51449 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal AIRE antibody |
AIRE antibody |
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70R-34455 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal AIRE antibody |
AIRE Antibody |
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33590-100ul | SAB | 100ul | EUR 302.4 |
AIRE Antibody |
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33590-50ul | SAB | 50ul | EUR 224.4 |
AIRE Antibody |
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32424-100ul | SAB | 100ul | EUR 302.4 |
AIRE Antibody |
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ABD3026 | Lifescience Market | 100 ug | EUR 525.6 |
AIRE Antibody |
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ABF0334 | Lifescience Market | 100 ug | EUR 525.6 |
AIRE Antibody |
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ABF5471 | Lifescience Market | 100 ug | EUR 525.6 |
AIRE Antibody |
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ABD6603 | Lifescience Market | 100 ug | EUR 525.6 |
AIRE Antibody |
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1-CSB-PA009261 | Cusabio |
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Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000 |
AIRE Antibody |
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DF6603 | Affbiotech | 200ul | EUR 420 |
AIRE Antibody |
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DF3026 | Affbiotech | 200ul | EUR 420 |
AIRE Antibody |
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CSB-PA274868- | Cusabio | each | EUR 402 |
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500 |
AIRE Antibody |
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CSB-PA274868-100ul | Cusabio | 100ul | EUR 379.2 |
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500 |
AIRE Antibody |
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1-CSB-PA000839 | Cusabio |
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Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/10000 |
AIRE Antibody |
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1-CSB-PA001502HA01HU | Cusabio |
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Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 |
AIRE Antibody |
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CSB-PA001502KA01HU- | Cusabio | each | EUR 402 |
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200 |
AIRE Antibody |
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CSB-PA001502KA01HU-100ul | Cusabio | 100ul | EUR 466.8 |
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200 |
AIRE Antibody |
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R35463-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Autoimmune regulator, APECED, Automimmune polyendocrinopathy candidiasis ectodermal dystrophy |
AIRE Antibody |
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R34350-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Autoimmune regulator protein |
AIRE Antibody |
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R34389-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), APECED |
AIRE Antibody |
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R32465 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). |
AIRE Rabbit pAb |
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A14183-100ul | Abclonal | 100 ul | EUR 369.6 |
AIRE Rabbit pAb |
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A14183-200ul | Abclonal | 200 ul | EUR 550.8 |
AIRE Rabbit pAb |
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A14183-20ul | Abclonal | 20 ul | EUR 219.6 |
AIRE Rabbit pAb |
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A14183-50ul | Abclonal | 50 ul | EUR 267.6 |
AIRE Rabbit pAb |
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A1767-100ul | Abclonal | 100 ul | EUR 369.6 |
AIRE Rabbit pAb |
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A1767-200ul | Abclonal | 200 ul | EUR 550.8 |
AIRE Rabbit pAb |
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A1767-20ul | Abclonal | 20 ul | EUR 219.6 |
AIRE Rabbit pAb |
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A1767-50ul | Abclonal | 50 ul | EUR 267.6 |
AIRE (isoform 1) |
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GT41000 | Neuromics | 100 ug | EUR 568.8 |
anti- AIRE antibody |
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FNab00241 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against AIRE |
AIRE (pS156) Antibody |
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abx332932-100ul | Abbexa | 100 ul | EUR 560.4 |
AIRE antibody (Ser156) |
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70R-34454 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal AIRE antibody (Ser156) |
AIRE Blocking Peptide |
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20-abx062024 | Abbexa |
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AIRE Blocking Peptide |
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AF0334-BP | Affbiotech | 1mg | EUR 234 |
AIRE Blocking Peptide |
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DF6603-BP | Affbiotech | 1mg | EUR 234 |
AIRE Blocking Peptide |
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DF3026-BP | Affbiotech | 1mg | EUR 234 |
Polyclonal AIRE Antibody |
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APR03336G | Leading Biology | 0.05ml | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AIRE . This antibody is tested and proven to work in the following applications: |
AIRE Conjugated Antibody |
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C32424 | SAB | 100ul | EUR 476.4 |
AIRE-1 Polyclonal Antibody |
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40562-100ul | SAB | 100ul | EUR 302.4 |
AIRE-1 Polyclonal Antibody |
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40562-50ul | SAB | 50ul | EUR 224.4 |
AIRE-1 Polyclonal Antibody |
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ABP50619-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of AIRE-1 from Human, Mouse. This AIRE-1 antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AIRE-1 at AA range: 60-140 |
AIRE-1 Polyclonal Antibody |
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ABP50619-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of AIRE-1 from Human, Mouse. This AIRE-1 antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AIRE-1 at AA range: 60-140 |
AIRE-1 Polyclonal Antibody |
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ABP50619-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of AIRE-1 from Human, Mouse. This AIRE-1 antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AIRE-1 at AA range: 60-140 |
AIRE-1 Polyclonal Antibody |
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ABP54773-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of AIRE-1 from Human. This AIRE-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156 |
AIRE-1 Polyclonal Antibody |
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ABP54773-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of AIRE-1 from Human. This AIRE-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156 |
AIRE-1 Polyclonal Antibody |
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ABP54773-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of AIRE-1 from Human. This AIRE-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156 |
AIRE-1 Polyclonal Antibody |
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ES1618-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA |
AIRE-1 Polyclonal Antibody |
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ES1618-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA |
AIRE-1 Polyclonal Antibody |
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ES5772-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
AIRE-1 Polyclonal Antibody |
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ES5772-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Rat AIRE ELISA Kit |
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ERA0534 | Abclonal | 96Tests | EUR 625.2 |
AIRE Cell ELISA Kit |
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abx595022-96tests | Abbexa | 96 tests | EUR 764.4 |
Goat AIRE ELISA Kit |
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EGTA0534 | Abclonal | 96Tests | EUR 625.2 |
Mouse AIRE ELISA Kit |
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EMA0534 | Abclonal | 96Tests | EUR 625.2 |
Sheep AIRE ELISA Kit |
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ESA0534 | Abclonal | 96Tests | EUR 625.2 |
Human AIRE ELISA Kit |
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ELA-E13302h | Lifescience Market | 96 Tests | EUR 988.8 |
AIRE ELISA KIT|Human |
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EF005361 | Lifescience Market | 96 Tests | EUR 826.8 |
Human AIRE ELISA Kit |
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EHA0534 | Abclonal | 96Tests | EUR 625.2 |
Monkey AIRE ELISA Kit |
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EMKA0534 | Abclonal | 96Tests | EUR 625.2 |
Rabbit AIRE ELISA Kit |
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ERTA0534 | Abclonal | 96Tests | EUR 625.2 |
Bovine AIRE ELISA Kit |
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EBA0534 | Abclonal | 96Tests | EUR 625.2 |
Canine AIRE ELISA Kit |
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ECA0534 | Abclonal | 96Tests | EUR 625.2 |
Porcine AIRE ELISA Kit |
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EPA0534 | Abclonal | 96Tests | EUR 625.2 |
Chicken AIRE ELISA Kit |
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ECKA0534 | Abclonal | 96Tests | EUR 625.2 |
Anserini AIRE ELISA Kit |
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EAA0534 | Abclonal | 96Tests | EUR 625.2 |
Human AIRE shRNA Plasmid |
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20-abx950227 | Abbexa |
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Mouse AIRE shRNA Plasmid |
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20-abx969093 | Abbexa |
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AIRE (Isoform 1) Antibody |
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abx432298-200ul | Abbexa | 200 ul | EUR 460.8 |
AIRE Antibody, HRP conjugated |
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1-CSB-PA001502HB01HU | Cusabio |
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Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
AIRE Recombinant Protein (Rat) |
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RP189656 | ABM | 100 ug | Ask for price |
AIRE Antibody, FITC conjugated |
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1-CSB-PA001502HC01HU | Cusabio |
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Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
AIRE (Phospho-Ser156) Antibody |
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11782-100ul | SAB | 100ul | EUR 302.4 |
AIRE (Phospho-Ser156) Antibody |
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11782-50ul | SAB | 50ul | EUR 224.4 |
AIRE Recombinant Protein (Mouse) |
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RP115070 | ABM | 100 ug | Ask for price |
AIRE Recombinant Protein (Human) |
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RP046219 | ABM | 100 ug | Ask for price |
AIRE Antibody, Biotin conjugated |
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1-CSB-PA001502HD01HU | Cusabio |
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Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
AIRE-1 Polyclonal Conjugated Antibody |
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C40562 | SAB | 100ul | EUR 476.4 |
Aire ORF Vector (Rat) (pORF) |
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ORF063220 | ABM | 1.0 ug DNA | EUR 607.2 |
Polyclonal AIRE Antibody (Internal) |
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APG00998G | Leading Biology | 0.05mg | EUR 580.8 |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human AIRE (Internal). This antibody is tested and proven to work in the following applications: |
Guinea Pig AIRE ELISA Kit |
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EGA0534 | Abclonal | 96Tests | EUR 625.2 |
Autoimmune Regulator (AIRE) Antibody |
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20-abx312575 | Abbexa |
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Autoimmune Regulator (AIRE) Antibody |
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abx230241-100ug | Abbexa | 100 ug | EUR 577.2 |
Autoimmune Regulator (AIRE) Antibody |
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20-abx175527 | Abbexa |
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Autoimmune Regulator (AIRE) Antibody |
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20-abx175528 | Abbexa |
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Autoimmune Regulator (AIRE) Antibody |
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20-abx175529 | Abbexa |
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