Th2 cells
th2cells

Escape from host Immune system

Posted on by Dominic

Involvement of PD-L1 on tumor cells within the escape from host immune system and tumor immunotherapy by PD-L1 blockade.

PD-1 is a receptor of the Ig superfamily that negatively regulates T cell antigen receptor signaling by interacting with the particular ligands (PD-L) and is usually recommended to play a task within the upkeep of self-tolerance. Within the current examine, we examined potential roles of the PD-1/PD-L system in tumor immunity.
Transgenic expression of PD-L1, one of many PD-L, in P815 tumor cells rendered them much less prone to the particular T cell antigen receptor-mediated lysis by cytotoxic T cells in vitro, and markedly enhanced their tumorigenesis and invasiveness in vivo within the syngeneic hosts as in contrast with the parental tumor cells that lacked endogenous PD-L.
Each results might be reversed by anti-PD-L1 Ab. Survey of murine tumor traces revealed that the entire myeloma cell traces examined naturally expressed PD-L1.

Rat Costimulatory molecules B7H4 ELISA equipment

Development of the myeloma cells in regular syngeneic mice was inhibited considerably albeit transiently by the administration of anti-PD-L1 Ab in vivo and was suppressed fully within the syngeneic PD-1-deficient mice.
These outcomes counsel that the expression of PD-L1 can function a potent mechanism for doubtlessly immunogenic tumors to flee from host immune responses and that blockade of interplay between PD-1 and PD-L might present a promising technique for particular tumor immunotherapy.

 

 

VTCN1 Antibody / B7H4
V7367-20UG 20 ug
EUR 153.3
Description: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

VTCN1 Antibody / B7H4
V7367IHC-7ML 7 ml
EUR 349.3
Description: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

VTCN1 Antibody / B7H4
V7367SAF-100UG 100 ug
EUR 349.3
Description: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

VTCN1 Antibody / B7H4
V8175-100UG 100 ug
EUR 349.3
Description: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

VTCN1 Antibody / B7H4
V8175-20UG 20 ug
EUR 153.3
Description: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

VTCN1 Antibody / B7H4
V8175SAF-100UG 100 ug
EUR 349.3
Description: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

B7H4 Antibody / VTCN1
RQ5561 100 ug
EUR 356.15
Description: V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene. It is mapped to 1p13.1-p12. This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

B7H4 antibody (biotin)
61R-1626 25 ug
EUR 340.8
Description: Mouse monoclonal B7H4 antibody (biotin)

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC942652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF594 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC942652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF594 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC802652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF680 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC802652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF680 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC702652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF770 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC702652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF770 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC882652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF488A conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC882652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF488A conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC812652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF680R conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC812652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF680R conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC402652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF640R conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC402652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF640R conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC052652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF405M conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC052652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF405M conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC042652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF405S conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC042652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF405S conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNCAP2652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNCAP2652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNCA2652-250 250uL
EUR 472.8
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), APC conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNCP2652-250 250uL
EUR 472.8
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), PerCP conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNCR2652-250 250uL
EUR 472.8
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), RPE conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNCH2652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNCH2652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNCB2652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), Biotin conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNCB2652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), Biotin conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNUB2652-100 100uL
EUR 316.8
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), Concentration: 0.2mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNUB2652-50 50uL
EUR 486
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), 1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNUB2652-500 500uL
EUR 615.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), Concentration: 0.2mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC472652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF647 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC472652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF647 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC552652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF555 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC552652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF555 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC612652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF660R conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC612652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF660R conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC432652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF543 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC432652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF543 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC682652-100 100uL
EUR 279.6
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF568 conjugate, Concentration: 0.1mg/mL

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody
BNC682652-500 500uL
EUR 654
Description: Primary antibody against B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), CF568 conjugate, Concentration: 0.1mg/mL

Rat Costimulatory molecules B7H4 ELISA kit
E02C0839-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Costimulatory molecules B7H4 ELISA kit
E02C0839-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Costimulatory molecules B7H4 ELISA kit
E02C0839-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Costimulatory molecules B7H4 ELISA kit
E08C0839-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Costimulatory molecules B7H4 ELISA kit
E08C0839-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Costimulatory molecules B7H4 ELISA kit
E08C0839-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Costimulatory molecules B7H4 ELISA kit
E07C0839-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Costimulatory molecules B7H4 ELISA kit
E07C0839-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Costimulatory molecules B7H4 ELISA kit
E07C0839-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Costimulatory molecules B7H4 ELISA kit
E06C0839-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Costimulatory molecules B7H4 ELISA kit
E06C0839-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Costimulatory molecules B7H4 ELISA kit
E06C0839-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Costimulatory molecules B7H4 ELISA kit
E01C0839-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Costimulatory molecules B7H4 ELISA kit
E01C0839-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Costimulatory molecules B7H4 ELISA kit
E01C0839-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Costimulatory molecules B7H4 ELISA kit
E03C0839-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Costimulatory molecules B7H4 ELISA kit
E03C0839-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Costimulatory molecules B7H4 ELISA kit
E03C0839-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Costimulatory molecules B7H4 ELISA kit
E04C0839-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Costimulatory molecules B7H4 ELISA kit
E04C0839-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Costimulatory molecules B7H4 ELISA kit
E04C0839-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Costimulatory molecules B7H4 ELISA kit
E09C0839-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Costimulatory molecules B7H4 ELISA kit
E09C0839-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Costimulatory molecules B7H4 ELISA kit
E09C0839-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), 0.2mg/mL
BNUB1788-100 1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), 0.2mg/mL
BNUB1788-500 1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), 1mg/mL
BNUM1788-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R), 1mg/mL
BNUM2652-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Guinea pig Costimulatory molecules B7H4 ELISA kit
E05C0839-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Costimulatory molecules B7H4 ELISA kit
E05C0839-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Costimulatory molecules B7H4 ELISA kit
E05C0839-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Costimulatory molecules B7H4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), CF568 conjugate, 0.1mg/mL
BNC681788-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), CF568 conjugate, 0.1mg/mL
BNC681788-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), CF647 conjugate, 0.1mg/mL
BNC471788-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), CF647 conjugate, 0.1mg/mL
BNC471788-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), CF594 conjugate, 0.1mg/mL
BNC941788-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), CF594 conjugate, 0.1mg/mL
BNC941788-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), CF640R conjugate, 0.1mg/mL
BNC401788-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), CF640R conjugate, 0.1mg/mL
BNC401788-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), CF405S conjugate, 0.1mg/mL
BNC041788-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

B7-H4 (Immuno-Inhibitory Protein)(B7H4/1788), CF405S conjugate, 0.1mg/mL
BNC041788-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

 

 

CRISPR/Cas, the immune system of micro organism and archaea.

 

 

Microbes depend on various protection mechanisms that permit them to face up to viral predation and publicity to invading nucleic acid. In lots of Micro organism and most Archaea, clustered usually interspaced quick palindromic repeats (CRISPR) type peculiar genetic loci, which give acquired immunity in opposition to viruses and plasmids by concentrating on nucleic acid in a sequence-specific method.

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody

These hypervariable loci take up genetic materials from invasive parts and construct up inheritable DNA-encoded immunity over time. Conversely, viruses have devised mutational escape methods that permit them to bypass the CRISPR/Cas system, albeit at a value.
CRISPR options could also be exploited for typing functions, epidemiological research, host-virus ecological surveys, constructing particular immunity in opposition to undesirable genetic parts, and enhancing viral resistance in domesticated microbes.

Regulation of Adaptive Immunity by the innate immune System

 

Twenty years after the proposal that sample recognition receptors detect invasion by microbial pathogens, the sphere of immunology has witnessed a number of discoveries which have elucidated receptors and signaling pathways of microbial recognition programs and the way they management the era of T and B lymphocyte-mediated immune responses.

Human vitamin, the intestine microbiome and the Immune System

Nevertheless, there are nonetheless many elementary questions that stay poorly understood, although typically the solutions are assumed to be recognized. Right here, we talk about a few of these questions, together with the mechanisms by which pathogen-specific innate immune recognition prompts antigen-specific adaptive immune responses and the roles of several types of innate immune recognition in host protection from an infection and harm.

 

 

Regulatory T cells and mechanisms of immune system management.

 

The immune system developed to guard the host in opposition to the assault of international, doubtlessly pathogenic, microorganisms. It does so by recognizing antigens expressed by these microorganisms and mounting an immune response in opposition to all cells expressing them, with the final word purpose of their elimination.
th2cells
th2cells
Varied mechanisms have been reported to manage and regulate the immune system to forestall or reduce reactivity to self-antigens or an overexuberant response to a pathogen, each of which may end up in harm to the host. Deletion of autoreactive cells throughout T- and B-cell improvement permits the immune system to be tolerant of most self-antigens.

B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R) Antibody

Peripheral tolerance to self was advised a number of years in the past to end result from the induction of anergy in peripheral self-reactive lymphocytes. Extra lately, nonetheless, it has develop into clear that avoidance of injury to the host can be achieved by lively suppression mediated by regulatory T (T(reg)) cell populations. We talk about right here the various mechanisms utilized by T(reg) cells to suppress the immune system.

 

 

FCRL4 Antibody
DF10173-100ul 100ul
EUR 280

FCRL4 Antibody
DF10173-200ul 200ul
EUR 350

FCRL4 Rabbit pAb
A10329-100ul 100 ul
EUR 369.6

FCRL4 Rabbit pAb
A10329-200ul 200 ul
EUR 550.8

FCRL4 Rabbit pAb
A10329-20ul 20 ul
EUR 219.6

FCRL4 Rabbit pAb
A10329-50ul 50 ul
EUR 267.6

FCRL4 Rabbit pAb
E2510329 100ul
EUR 225
Description: Available in various conjugation types.

FCRL4 cloning plasmid
CSB-CL836277HU-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the FCRL4 gene.

FCRL4 Blocking Peptide
33R-2948 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FCRL4 antibody, catalog no. 70R-7228

FCRL4 Blocking Peptide
33R-4431 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FCRL4 antibody, catalog no. 70R-7229

FCRL4 Blocking Peptide
DF10173-BP 1mg
EUR 234

FCRL4 Polyclonal Antibody
27378-100ul 100ul
EUR 302.4

FCRL4 Polyclonal Antibody
27378-50ul 50ul
EUR 224.4

FCRL4 Polyclonal Antibody
A71988
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

FCRL4 Polyclonal Antibody
ABP58542-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FCRL4 from Human. This FCRL4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human FCRL4 protein

FCRL4 Polyclonal Antibody
ABP58542-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FCRL4 from Human. This FCRL4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human FCRL4 protein

FCRL4 Polyclonal Antibody
ABP58542-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FCRL4 from Human. This FCRL4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human FCRL4 protein

FCRL4 Polyclonal Antibody
A59118
  • EUR 684.66
  • Ask for price
  • Ask for price
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

FCRL4 Polyclonal Antibody
ES10946-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against FCRL4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

FCRL4 Polyclonal Antibody
ES10946-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against FCRL4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

FCRL4 Polyclonal Antibody
E11-202000 100ug/100ul
EUR 225
Description: Available in various conjugation types.

FCRL4 Polyclonal Antibody
E910329 100ul
EUR 225
Description: Available in various conjugation types.

Human FCRL4 shRNA Plasmid
20-abx963092
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

FCRL4 Antibody, HRP conjugated
1-CSB-PA836277LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FCRL4. Recognizes FCRL4 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

FCRL4 Antibody, FITC conjugated
1-CSB-PA836277LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FCRL4. Recognizes FCRL4 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

FCRL4 Recombinant Protein (Human)
RP039067 100 ug Ask for price

FCRL4 Antibody, Biotin conjugated
1-CSB-PA836277LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FCRL4. Recognizes FCRL4 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

FCRL4 (C-term) Rabbit pAb
E2620213 100ul
EUR 225
Description: Available in various conjugation types.

FCRL4 Polyclonal Conjugated Antibody
C27378 100ul
EUR 476.4

FCRL4 ORF Vector (Human) (pORF)
ORF013023 1.0 ug DNA
EUR 114

PE anti-human CD307d (FcRL4)
E16FHP307d-025 25 tests
EUR 520
Description: Available in various conjugation types.

PE anti-human CD307d (FcRL4)
E16FHP307d-100 100 tests
EUR 1278.33
Description: Available in various conjugation types.

APC anti-human CD307d (FcRL4)
E16FHA307d-025 25 tests
EUR 541.67
Description: Available in various conjugation types.

APC anti-human CD307d (FcRL4)
E16FHA307d-100 100 tests
EUR 1321.67
Description: Available in various conjugation types.

Human FCRL4 Protein Lysate 20ug
IHUFCRL4PLLY20UG each
EUR 361
Description: Human FCRL4 Protein Lysate 20ug

Polyclonal FCRL4 Antibody (C-term)
APR06205G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FCRL4 (C-term). This antibody is tested and proven to work in the following applications:

Purified anti-human CD307d (FcRL4)
E16FHU307d-100U 100 μg
EUR 1191.67
Description: Available in various conjugation types.

FCRL4 Polyclonal Antibody, HRP Conjugated
A59121
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

FCRL4 Polyclonal Antibody, FITC Conjugated
A59120
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

PE-Cy7 anti-human CD307d (FcRL4)
E16FHN307d-100 100 tests
EUR 1408.33
Description: Available in various conjugation types.

FCRL4 Polyclonal Antibody, Biotin Conjugated
A59119
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

FCRL4 sgRNA CRISPR Lentivector set (Human)
K0771001 3 x 1.0 ug
EUR 406.8

FCRL4 3'UTR GFP Stable Cell Line
TU057851 1.0 ml
EUR 1825.2

Rabbit Anti-Human FCRL4 polyclonal antibody
CABT-BL140 100 ul
EUR 702

FCRL4 Protein Vector (Human) (pPM-C-HA)
PV052091 500 ng
EUR 577.2

FCRL4 Protein Vector (Human) (pPB-C-His)
PV052089 500 ng
EUR 577.2

FCRL4 Protein Vector (Human) (pPB-N-His)
PV052090 500 ng
EUR 577.2

FCRL4 Protein Vector (Human) (pPM-C-His)
PV052092 500 ng
EUR 577.2

FCRL4 3'UTR Luciferase Stable Cell Line
TU007851 1.0 ml
EUR 1825.2

Human Fc receptor-like protein 4 (FCRL4)
1-CSB-EP836277HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Fc receptor-like protein 4(FCRL4),partial expressed in E.coli

Human Fc receptor-like protein 4 (FCRL4)
1-CSB-YP836277HU
  • EUR 604.80
  • EUR 318.00
  • EUR 2198.40
  • EUR 915.60
  • EUR 1459.20
  • EUR 400.80
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Fc receptor-like protein 4(FCRL4),partial expressed in Yeast

Human Fc receptor-like protein 4 (FCRL4)
1-CSB-MP836277HU
  • EUR 351.60
  • EUR 1155.60
  • EUR 490.80
  • EUR 860.40
  • 100ug
  • 1MG
  • 200ug
  • 500ug
Description: Recombinant Human Fc receptor-like protein 4 (FCRL4) expressed in Mammalian cell

Fc Receptor-Like Protein 4 (FCRL4) Antibody
20-abx318313
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fc Receptor-Like Protein 4 (FCRL4) Antibody
abx037262-100ug 100 ug
EUR 469.2

Fc Receptor-Like Protein 4 (FCRL4) Antibody
20-abx125844
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

FCRL4 sgRNA CRISPR Lentivector (Human) (Target 1)
K0771002 1.0 ug DNA
EUR 184.8

FCRL4 sgRNA CRISPR Lentivector (Human) (Target 2)
K0771003 1.0 ug DNA
EUR 184.8

FCRL4 sgRNA CRISPR Lentivector (Human) (Target 3)
K0771004 1.0 ug DNA
EUR 184.8

Fc Receptor-Like Protein 4 (FCRL4) Antibody (HRP)
20-abx309173
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fc Receptor-Like Protein 4 (FCRL4) Antibody (FITC)
20-abx309174
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Fc Receptor-Like Protein 4 (FCRL4) Antibody (Biotin)
20-abx309175
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Fc receptor- like protein 4, FCRL4 ELISA KIT
ELI-43914h 96 Tests
EUR 988.8

Human Fc receptor-like protein 4(FCRL4) ELISA Kit
NSL0617Hu 96 wells
EUR 468

FCRL4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K0771005 3 x 1.0 ug
EUR 451.2

FCRL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K0771006 1.0 ug DNA
EUR 200.4

FCRL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K0771007 1.0 ug DNA
EUR 200.4

FCRL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K0771008 1.0 ug DNA
EUR 200.4

h FcRL3
LVP935 1x107 IFU/ml x 200ul
EUR 541.2
Description: Pre-made over-expression lentivirus for expressing human target: FCRL3 (Fc receptor like 3), [alternative names: FCRH3; IFGP3; IRTA3; SPAP2; CD307c]. The sub-cloned codon sequence is identical (100% match) to CDS region in NCBI ID: NM_001320333.1. It also contains a RFP-Blasticidin dual selection marker.

FCRL1 siRNA
20-abx916711
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FCRL1 siRNA
20-abx916712
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FCRL2 siRNA
20-abx916713
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FCRL3 siRNA
20-abx916714
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FCRL5 siRNA
20-abx916716
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FCRL5 siRNA
20-abx916717
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FCRL6 siRNA
20-abx916718
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FCRL6 siRNA
20-abx916719
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FCRL1 Peptide
43-660P 0.1 mg
EUR 405.6

FCRL1 Peptide
43-662P 0.1 mg
EUR 405.6

FCRL2 Peptide
43-663P 0.1 mg
EUR 405.6

FCRL2 Rabbit pAb
A10324-100ul 100 ul
EUR 369.6

FCRL2 Rabbit pAb
A10324-200ul 200 ul
EUR 550.8

FCRL2 Rabbit pAb
A10324-20ul 20 ul
EUR 219.6

FCRL2 Rabbit pAb
A10324-50ul 50 ul
EUR 267.6

FCRL3 Rabbit pAb
A10451-100ul 100 ul
EUR 369.6

FCRL3 Rabbit pAb
A10451-200ul 200 ul
EUR 550.8

FCRL3 Rabbit pAb
A10451-20ul 20 ul
EUR 219.6

FCRL3 Rabbit pAb
A10451-50ul 50 ul
EUR 267.6

FCRL3 Rabbit pAb
A10452-100ul 100 ul
EUR 369.6

FCRL3 Rabbit pAb
A10452-200ul 200 ul
EUR 550.8

FCRL3 Rabbit pAb
A10452-20ul 20 ul
EUR 219.6

FCRL3 Rabbit pAb
A10452-50ul 50 ul
EUR 267.6

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