th2cells

 Immune System to Anticancer Chemotherapy And Radiotherapy.

Posted on by Dominic

 

Interactions between the microbiota and the immune system.

 

 

The massive numbers of microorganisms that inhabit mammalian physique surfaces have a extremely coevolved relationship with the immune system. Though many of those microbes perform features which might be important for host physiology, they however pose the specter of breach with ensuing pathologies.
The mammalian immune system performs an important function in sustaining homeostasis with resident microbial communities, thus guaranteeing that the mutualistic nature of the host-microbial relationship is maintained. On the identical time, resident micro organism profoundly form mammalian immunity.
Right here, we assessment advances in our understanding of the interactions between resident microbes and the immune system and the implications of those findings for human well being.

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.

Typical most cancers remedies depend on radiotherapy and chemotherapy. Such remedies supposedly mediate their results through the direct elimination of tumor cells. Right here we present that the success of some protocols for anticancer remedy will depend on innate and adaptive antitumor immune responses.
th2cells
th2cells
We describe in each mice and people a beforehand unrecognized pathway for the activation of tumor antigen-specific T-cell immunity that entails secretion of the high-mobility-group field 1 (HMGB1) alarmin protein by dying tumor cells and the motion of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs).

CIC Polyclonal Antibody
Throughout chemotherapy or radiotherapy, DCs require signaling by way of TLR4 and its adaptor MyD88 for environment friendly processing and cross-presentation of antigen from dying tumor cells.
Sufferers with breast most cancers who carry a TLR4 loss-of-function allele relapse extra rapidly after radiotherapy and chemotherapy than these carrying the traditional TLR4 allele. These outcomes delineate a clinically related immunoadjuvant pathway triggered by tumor cell dying.

 

CIC antibody
70R-51366 100 ul
EUR 244
Description: Purified Polyclonal CIC antibody

CIC Antibody
ABD10074 100 ug
EUR 438

CIC Antibody
44496-100ul 100ul
EUR 252

CIC Antibody
44496-50ul 50ul
EUR 187

CIC Antibody
DF10074 200ul
EUR 304
Description: CIC Antibody detects endogenous levels of total CIC.

CIC Conjugated Antibody
C44496 100ul
EUR 397

anti- CIC antibody
FNab10183 100µg
EUR 505.25
  • Recommended dilution: IHC: 1:50-1:500
  • Immunogen: Protein capicua homolog
  • Uniprot ID: Q96RK0
  • Gene ID: 6576
Description: Antibody raised against CIC

CIC Polyclonal Antibody
ES10630-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against CIC from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

CIC Polyclonal Antibody
ES10630-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against CIC from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

CIC Blocking Peptide
20-abx064241
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

CIC Polyclonal Antibody
ABP58155-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from part region of human CIC protein at amino acid sequence of 550-630
  • Applications tips:
Description: A polyclonal antibody for detection of CIC from Human, Mouse. This CIC antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CIC protein at amino acid sequence of 550-630

CIC Polyclonal Antibody
ABP58155-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from part region of human CIC protein at amino acid sequence of 550-630
  • Applications tips:
Description: A polyclonal antibody for detection of CIC from Human, Mouse. This CIC antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CIC protein at amino acid sequence of 550-630

CIC Polyclonal Antibody
ABP58155-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from part region of human CIC protein at amino acid sequence of 550-630
  • Applications tips:
Description: A polyclonal antibody for detection of CIC from Human, Mouse. This CIC antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CIC protein at amino acid sequence of 550-630

Anti-CIC Antibody
A00385-1 100ug/vial
EUR 334

CIC Rabbit pAb
A15408-100ul 100 ul
EUR 308

CIC Rabbit pAb
A15408-200ul 200 ul
EUR 459

CIC Rabbit pAb
A15408-20ul 20 ul
EUR 183

CIC Rabbit pAb
A15408-50ul 50 ul
EUR 223

CIC Blocking Peptide
DF10074-BP 1mg
EUR 195

Anti-CIC antibody
STJ117603 100 µl
EUR 277
Description: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Anti-CIC antibody
STJ191788 200 µl
EUR 197
Description: Unconjugated Rabbit polyclonal to CIC

Mouse CIC shRNA Plasmid
20-abx977476
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

Human CIC ELISA Kit
EHC0248 96Tests
EUR 521

Goat CIC ELISA Kit
EGTC0248 96Tests
EUR 521

Canine CIC ELISA Kit
ECC0248 96Tests
EUR 521

Chicken CIC ELISA Kit
ECKC0248 96Tests
EUR 521

Bovine CIC ELISA Kit
EBC0248 96Tests
EUR 521

Anserini CIC ELISA Kit
EAC0248 96Tests
EUR 521

CIC ELISA KIT|Human
EF010611 96 Tests
EUR 689

CIC ELISA KIT|Human
EF010614 96 Tests
EUR 689

Porcine CIC ELISA Kit
EPC0248 96Tests
EUR 521

Rat CIC ELISA Kit
ERC0248 96Tests
EUR 521

Rabbit CIC ELISA Kit
ERTC0248 96Tests
EUR 521

Sheep CIC ELISA Kit
ESC0248 96Tests
EUR 521

Mouse CIC ELISA Kit
EMC0248 96Tests
EUR 521

Monkey CIC ELISA Kit
EMKC0248 96Tests
EUR 521

Human CIC shRNA Plasmid
20-abx958038
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

Guinea Pig CIC ELISA Kit
EGC0248 96Tests
EUR 521

Protein Capicua Homolog (CIC) Antibody
20-abx149340
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protein Capicua Homolog (CIC) Antibody
20-abx007791
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Cic ORF Vector (Rat) (pORF)
ORF065019 1.0 ug DNA
EUR 2080

Cic ORF Vector (Mouse) (pORF)
ORF041397 1.0 ug DNA
EUR 1572

Cic ORF Vector (Mouse) (pORF)
ORF041398 1.0 ug DNA
EUR 1572

Cic ORF Vector (Mouse) (pORF)
ORF041399 1.0 ug DNA
EUR 1572

CIC ORF Vector (Human) (pORF)
ORF017390 1.0 ug DNA Ask for price

pECMV-Cic-m-FLAG Plasmid
PVT15489 2 ug
EUR 325

pECMV-Cic-m-FLAG Plasmid
PVT15770 2 ug
EUR 325

CIC sgRNA CRISPR Lentivector set (Human)
K0453101 3 x 1.0 ug
EUR 339

Cic sgRNA CRISPR Lentivector set (Rat)
K6212001 3 x 1.0 ug
EUR 339

Cic sgRNA CRISPR Lentivector set (Mouse)
K4044901 3 x 1.0 ug
EUR 339

Goat capicua homolog (Drosophila) (CIC) ELISA kit
E06C1725-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Goat capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat capicua homolog (Drosophila) (CIC) ELISA kit
E06C1725-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Goat capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat capicua homolog (Drosophila) (CIC) ELISA kit
E06C1725-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Goat capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat capicua homolog (Drosophila) (CIC) ELISA kit
E02C1725-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat capicua homolog (Drosophila) (CIC) ELISA kit
E02C1725-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat capicua homolog (Drosophila) (CIC) ELISA kit
E02C1725-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse capicua homolog (Drosophila) (CIC) ELISA kit
E03C1725-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse capicua homolog (Drosophila) (CIC) ELISA kit
E03C1725-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse capicua homolog (Drosophila) (CIC) ELISA kit
E03C1725-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit capicua homolog (Drosophila) (CIC) ELISA kit
E04C1725-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit capicua homolog (Drosophila) (CIC) ELISA kit
E04C1725-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit capicua homolog (Drosophila) (CIC) ELISA kit
E04C1725-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human capicua homolog (Drosophila) (CIC) ELISA kit
E01C1725-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human capicua homolog (Drosophila) (CIC) ELISA kit
E01C1725-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human capicua homolog (Drosophila) (CIC) ELISA kit
E01C1725-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig capicua homolog (Drosophila) (CIC) ELISA kit
E07C1725-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Porcine capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig capicua homolog (Drosophila) (CIC) ELISA kit
E07C1725-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Porcine capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig capicua homolog (Drosophila) (CIC) ELISA kit
E07C1725-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Porcine capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog capicua homolog (Drosophila) (CIC) ELISA kit
E08C1725-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Canine capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog capicua homolog (Drosophila) (CIC) ELISA kit
E08C1725-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Canine capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog capicua homolog (Drosophila) (CIC) ELISA kit
E08C1725-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Canine capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey capicua homolog (Drosophila) (CIC) ELISA kit
E09C1725-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Monkey capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey capicua homolog (Drosophila) (CIC) ELISA kit
E09C1725-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Monkey capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey capicua homolog (Drosophila) (CIC) ELISA kit
E09C1725-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Monkey capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Protein capicua homolog, CIC ELISA KIT
ELI-10277h 96 Tests
EUR 824

Human circulating immune complex(CIC)ELISA Kit
GA-E0366HM-48T 48T
EUR 289

Human circulating immune complex(CIC)ELISA Kit
GA-E0366HM-96T 96T
EUR 466

 

 

 

An immunomodulatory molecule of symbiotic micro organism directs maturation of the host immune system.

 

The mammalian gastrointestinal tract harbors a fancy ecosystem consisting of numerous micro organism in homeostasis with the host immune system. Formed by evolution, this partnership has potential for symbiotic profit. Nevertheless, the identities of bacterial molecules mediating symbiosis stay undefined.
Right here we present that, throughout colonization of animals with the ever-present intestine microorganism Bacteroides fragilis, a bacterial polysaccharide (PSA) directs the mobile and bodily maturation of the creating immune system. Comparability with germ-free animals reveals that the immunomodulatory actions of PSA throughout B. fragilis colonization embody correcting systemic  ore intersting facts about the class is in Sainik school coaching in dehradun, T cell deficiencies and T(H)1/T(H)2 imbalances and directing lymphoid organogenesis.

Anti-CIC antibody

Description: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the excessive mobility group (HMG)-box superfamily of transcriptional repressors. This protein accommodates a conserved HMG area that’s concerned in DNA binding and nuclear localization, and a conserved C-terminus. Research recommend that the N-terminal area of this protein interacts with Atxn1 (GeneID:6310), to kind a transcription repressor advanced, and in vitro research recommend that polyglutamine-expansion of ATXN1 might alter the repressor exercise of this advanced.

Mutations on this gene have been related to olidogdendrogliomas (PMID:21817013). As well as, translocation occasions leading to gene fusions of this gene with each DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been related to spherical cell sarcomas. There are a number of pseudogenes of this gene discovered on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Various splicing leads to a number of transcript variants encoding completely different isoforms.
A PSA mutant of B. fragilis doesn’t restore these immunologic features. PSA introduced by intestinal dendritic cells prompts CD4+ T cells and elicits acceptable cytokine manufacturing. These findings present a molecular foundation for host-bacterial symbiosis and reveal the archetypal molecule of commensal micro organism that mediates growth of the host immune system.

Paradoxical roles of the immune system Throughout most cancers Improvement

 

The primary operate of the mammalian immune system is to observe tissue homeostasis, to guard in opposition to invading or infectious pathogens and to eradicate broken cells. Due to this fact, it’s stunning that most cancers happens with such a excessive frequency in people.

Human capicua homolog (Drosophila) (CIC) ELISA equipment

 

Current insights which have been gained from scientific research and experimental mouse fashions of carcinogenesis increase our understanding of the advanced relationship between immune cells and creating tumours. Right here, we look at the paradoxical function of adaptive and innate leukocytes as essential regulators of most cancers growth and spotlight latest insights which have been gained by manipulating immune responses in mouse fashions of de novo and spontaneous tumorigenesis.

 

 

 

IRG1 Antibody
DF7723 200ul
EUR 304
Description: IRG1 Antibody detects endogenous levels of total IRG1.
IRG1 Conjugated Antibody
C45116 100ul
EUR 397
IRG1 Blocking Peptide
DF7723-BP 1mg
EUR 195
Human IRG1 shRNA Plasmid
20-abx968755
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.
Mouse IRG1 shRNA Plasmid
20-abx971074
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.
IRG1 Recombinant Protein (Human)
RP065916 100 ug Ask for price
IRG1 Recombinant Protein (Rat)
RP206252 100 ug Ask for price
IRG1 Recombinant Protein (Mouse)
RP144233 100 ug Ask for price
Irg1 ORF Vector (Rat) (pORF)
ORF068752 1.0 ug DNA
EUR 506
Irg1 ORF Vector (Mouse) (pORF)
ORF048079 1.0 ug DNA
EUR 95
IRG1 ORF Vector (Human) (pORF)
ORF021973 1.0 ug DNA Ask for price
IRG1 sgRNA CRISPR Lentivector set (Human)
K1099201 3 x 1.0 ug
EUR 339
Irg1 sgRNA CRISPR Lentivector set (Mouse)
K3063001 3 x 1.0 ug
EUR 339
Irg1 sgRNA CRISPR Lentivector set (Rat)
K6650801 3 x 1.0 ug
EUR 339
Immune-Responsive Gene 1 Protein (IRG1) Antibody
20-abx216312
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.
IRG1 sgRNA CRISPR Lentivector (Human) (Target 1)
K1099202 1.0 ug DNA
EUR 154
IRG1 sgRNA CRISPR Lentivector (Human) (Target 2)
K1099203 1.0 ug DNA
EUR 154
IRG1 sgRNA CRISPR Lentivector (Human) (Target 3)
K1099204 1.0 ug DNA
EUR 154
Irg1 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K3063002 1.0 ug DNA
EUR 154
Irg1 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K3063003 1.0 ug DNA
EUR 154
Irg1 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K3063004 1.0 ug DNA
EUR 154
Irg1 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6650802 1.0 ug DNA
EUR 154
Irg1 sgRNA CRISPR Lentivector (Rat) (Target 2)
K6650803 1.0 ug DNA
EUR 154
Irg1 sgRNA CRISPR Lentivector (Rat) (Target 3)
K6650804 1.0 ug DNA
EUR 154
IRG1 Protein Vector (Human) (pPB-C-His)
PV087890 500 ng Ask for price
IRG1 Protein Vector (Human) (pPB-N-His)
PV087891 500 ng Ask for price
IRG1 Protein Vector (Human) (pPM-C-HA)
PV087892 500 ng Ask for price
IRG1 Protein Vector (Human) (pPM-C-His)
PV087893 500 ng Ask for price
IRG1 Protein Vector (Rat) (pPB-C-His)
PV275006 500 ng
EUR 603
IRG1 Protein Vector (Rat) (pPB-N-His)
PV275007 500 ng
EUR 603
IRG1 Protein Vector (Rat) (pPM-C-HA)
PV275008 500 ng
EUR 603
IRG1 Protein Vector (Rat) (pPM-C-His)
PV275009 500 ng
EUR 603
IRG1 Protein Vector (Mouse) (pPB-C-His)
PV192314 500 ng
EUR 603
IRG1 Protein Vector (Mouse) (pPB-N-His)
PV192315 500 ng
EUR 603
IRG1 Protein Vector (Mouse) (pPM-C-HA)
PV192316 500 ng
EUR 603
IRG1 Protein Vector (Mouse) (pPM-C-His)
PV192317 500 ng
EUR 603
Irg1 3'UTR Luciferase Stable Cell Line
TU206379 1.0 ml Ask for price
Irg1 3'UTR GFP Stable Cell Line
TU160220 1.0 ml Ask for price
IRG1 3'UTR Luciferase Stable Cell Line
TU011267 1.0 ml
EUR 1394
Irg1 3'UTR Luciferase Stable Cell Line
TU110220 1.0 ml Ask for price
IRG1 3'UTR GFP Stable Cell Line
TU061267 1.0 ml
EUR 1394
Irg1 3'UTR GFP Stable Cell Line
TU256379 1.0 ml Ask for price
IRG1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)
LV622081 1.0 ug DNA
EUR 682
IRG1 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
LV622085 1.0 ug DNA
EUR 682
IRG1 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)
LV622086 1.0 ug DNA
EUR 682
Mouse IRG1 (Immune- responsive gene 1 protein) ELISA Kit (CUSTOM
ELI-08257m 96 Tests
EUR 865
Human IRG1 (Immune- responsive gene 1 protein homolog) ELISA Kit
ELI-28070h 96 Tests
EUR 824
IRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K1099205 3 x 1.0 ug
EUR 376
Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K3063005 3 x 1.0 ug
EUR 376
Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
K6650805 3 x 1.0 ug
EUR 376
IRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K1099206 1.0 ug DNA
EUR 167
IRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K1099207 1.0 ug DNA
EUR 167
IRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K1099208 1.0 ug DNA
EUR 167
Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K3063006 1.0 ug DNA
EUR 167
Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K3063007 1.0 ug DNA
EUR 167
Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K3063008 1.0 ug DNA
EUR 167
Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)
K6650806 1.0 ug DNA
EUR 167
Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)
K6650807 1.0 ug DNA
EUR 167
Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)
K6650808 1.0 ug DNA
EUR 167
IRG1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)
LV622082 1.0 ug DNA
EUR 682
IRG1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)
LV622083 1.0 ug DNA
EUR 740
IRG1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
LV622084 1.0 ug DNA
EUR 740

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