Th2 cells
th2cells

 Immune System to Anticancer Chemotherapy And Radiotherapy.

Posted on by Dominic

 

Interactions between the microbiota and the immune system.

 

 

The massive numbers of microorganisms that inhabit mammalian physique surfaces have a extremely coevolved relationship with the immune system. Though many of those microbes perform features which might be important for host physiology, they however pose the specter of breach with ensuing pathologies.
The mammalian immune system performs an important function in sustaining homeostasis with resident microbial communities, thus guaranteeing that the mutualistic nature of the host-microbial relationship is maintained. On the identical time, resident micro organism profoundly form mammalian immunity.
Right here, we assessment advances in our understanding of the interactions between resident microbes and the immune system and the implications of those findings for human well being.

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.

Typical most cancers remedies depend on radiotherapy and chemotherapy. Such remedies supposedly mediate their results through the direct elimination of tumor cells. Right here we present that the success of some protocols for anticancer remedy will depend on innate and adaptive antitumor immune responses.
th2cells
th2cells
We describe in each mice and people a beforehand unrecognized pathway for the activation of tumor antigen-specific T-cell immunity that entails secretion of the high-mobility-group field 1 (HMGB1) alarmin protein by dying tumor cells and the motion of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs).

CIC Polyclonal Antibody
Throughout chemotherapy or radiotherapy, DCs require signaling by way of TLR4 and its adaptor MyD88 for environment friendly processing and cross-presentation of antigen from dying tumor cells.
Sufferers with breast most cancers who carry a TLR4 loss-of-function allele relapse extra rapidly after radiotherapy and chemotherapy than these carrying the traditional TLR4 allele. These outcomes delineate a clinically related immunoadjuvant pathway triggered by tumor cell dying.

 

CIC antibody
70R-51366 100 ul
EUR 292.8
Description: Purified Polyclonal CIC antibody

CIC Antibody
ABD10074 100 ug
EUR 525.6

CIC Antibody
DF10074 200ul
EUR 420

CIC Rabbit pAb
A15408-100ul 100 ul
EUR 369.6

CIC Rabbit pAb
A15408-200ul 200 ul
EUR 550.8

CIC Rabbit pAb
A15408-20ul 20 ul
EUR 219.6

CIC Rabbit pAb
A15408-50ul 50 ul
EUR 267.6

anti- CIC antibody
FNab10183 100µg
EUR 606.3
Description: Antibody raised against CIC

CIC Blocking Peptide
20-abx064241
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

CIC Blocking Peptide
DF10074-BP 1mg
EUR 234

Capicua Antibody / CIC
RQ4551 100ug
EUR 356.15
Description: Protein capicua homolog is a protein that in humans is encoded by the CIC gene. The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. This gene is mapped to 19q13.2. Alternative splicing results in multiple transcript variants encoding different isoforms.

CIC Conjugated Antibody
C44496 100ul
EUR 476.4

CIC Polyclonal Antibody
ABP58155-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of CIC from Human, Mouse. This CIC antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CIC protein at amino acid sequence of 550-630

CIC Polyclonal Antibody
ABP58155-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of CIC from Human, Mouse. This CIC antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CIC protein at amino acid sequence of 550-630

CIC Polyclonal Antibody
ABP58155-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of CIC from Human, Mouse. This CIC antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CIC protein at amino acid sequence of 550-630

CIC Polyclonal Antibody
ES10630-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against CIC from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

CIC Polyclonal Antibody
ES10630-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against CIC from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Rat CIC ELISA Kit
ERC0248 96Tests
EUR 625.2

Goat CIC ELISA Kit
EGTC0248 96Tests
EUR 625.2

Mouse CIC ELISA Kit
EMC0248 96Tests
EUR 625.2

Sheep CIC ELISA Kit
ESC0248 96Tests
EUR 625.2

CIC ELISA KIT|Human
EF010611 96 Tests
EUR 826.8

CIC ELISA KIT|Human
EF010614 96 Tests
EUR 826.8

Human CIC ELISA Kit
EHC0248 96Tests
EUR 625.2

Monkey CIC ELISA Kit
EMKC0248 96Tests
EUR 625.2

Rabbit CIC ELISA Kit
ERTC0248 96Tests
EUR 625.2

Bovine CIC ELISA Kit
EBC0248 96Tests
EUR 625.2

Canine CIC ELISA Kit
ECC0248 96Tests
EUR 625.2

Porcine CIC ELISA Kit
EPC0248 96Tests
EUR 625.2

Chicken CIC ELISA Kit
ECKC0248 96Tests
EUR 625.2

Anserini CIC ELISA Kit
EAC0248 96Tests
EUR 625.2

Human CIC shRNA Plasmid
20-abx958038
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse CIC shRNA Plasmid
20-abx977476
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

CLCN5 Antibody / CIC-5 antibody
RQ6462 100ug
EUR 356.15
Description: The CLCN5 gene encodes the chloride channel Cl-/H+ exchanger ClC-5. This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene.

Cic ORF Vector (Rat) (pORF)
ORF065019 1.0 ug DNA
EUR 2496

Guinea Pig CIC ELISA Kit
EGC0248 96Tests
EUR 625.2

CIC ORF Vector (Human) (pORF)
ORF017390 1.0 ug DNA Ask for price

Cic ORF Vector (Mouse) (pORF)
ORF041397 1.0 ug DNA
EUR 1886.4

Cic ORF Vector (Mouse) (pORF)
ORF041398 1.0 ug DNA
EUR 1886.4

Cic ORF Vector (Mouse) (pORF)
ORF041399 1.0 ug DNA
EUR 1886.4

Protein Capicua Homolog (CIC) Antibody
20-abx149340
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Protein Capicua Homolog (CIC) Antibody
20-abx007791
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Cic sgRNA CRISPR Lentivector set (Rat)
K6212001 3 x 1.0 ug
EUR 406.8

CIC sgRNA CRISPR Lentivector set (Human)
K0453101 3 x 1.0 ug
EUR 406.8

Cic sgRNA CRISPR Lentivector set (Mouse)
K4044901 3 x 1.0 ug
EUR 406.8

Cic 3'UTR GFP Stable Cell Line
TU153908 1.0 ml Ask for price

CIC 3'UTR GFP Stable Cell Line
TU054436 1.0 ml
EUR 1672.8

Cic 3'UTR GFP Stable Cell Line
TU252360 1.0 ml Ask for price

CIC Protein Vector (Rat) (pPM-C-HA)
PV260076 500 ng
EUR 3237.6

CIC Protein Vector (Rat) (pPB-C-His)
PV260074 500 ng
EUR 3237.6

CIC Protein Vector (Rat) (pPB-N-His)
PV260075 500 ng
EUR 3237.6

CIC Protein Vector (Rat) (pPM-C-His)
PV260077 500 ng
EUR 3237.6

CIC Protein Vector (Mouse) (pPM-C-HA)
PV165588 500 ng
EUR 3235.2

CIC Protein Vector (Mouse) (pPM-C-HA)
PV165592 500 ng
EUR 3234

CIC Protein Vector (Mouse) (pPM-C-HA)
PV165596 500 ng
EUR 3235.2

CIC Protein Vector (Human) (pPM-C-HA)
PV069559 500 ng Ask for price

CIC Protein Vector (Mouse) (pPB-C-His)
PV165586 500 ng
EUR 3235.2

CIC Protein Vector (Mouse) (pPB-N-His)
PV165587 500 ng
EUR 3235.2

CIC Protein Vector (Mouse) (pPM-C-His)
PV165589 500 ng
EUR 3235.2

CIC Protein Vector (Mouse) (pPB-C-His)
PV165590 500 ng
EUR 3234

CIC Protein Vector (Mouse) (pPB-N-His)
PV165591 500 ng
EUR 3234

CIC Protein Vector (Mouse) (pPM-C-His)
PV165593 500 ng
EUR 3234

CIC Protein Vector (Mouse) (pPB-C-His)
PV165594 500 ng
EUR 3235.2

CIC Protein Vector (Mouse) (pPB-N-His)
PV165595 500 ng
EUR 3235.2

CIC Protein Vector (Mouse) (pPM-C-His)
PV165597 500 ng
EUR 3235.2

CIC Protein Vector (Human) (pPB-C-His)
PV069557 500 ng Ask for price

CIC Protein Vector (Human) (pPB-N-His)
PV069558 500 ng Ask for price

CIC Protein Vector (Human) (pPM-C-His)
PV069560 500 ng Ask for price

CIC 3'UTR Luciferase Stable Cell Line
TU004436 1.0 ml
EUR 1672.8

Cic 3'UTR Luciferase Stable Cell Line
TU103908 1.0 ml Ask for price

Cic 3'UTR Luciferase Stable Cell Line
TU202360 1.0 ml Ask for price

Cic sgRNA CRISPR Lentivector (Rat) (Target 1)
K6212002 1.0 ug DNA
EUR 184.8

Cic sgRNA CRISPR Lentivector (Rat) (Target 2)
K6212003 1.0 ug DNA
EUR 184.8

Cic sgRNA CRISPR Lentivector (Rat) (Target 3)
K6212004 1.0 ug DNA
EUR 184.8

Mouse Protein capicua homolog, Cic ELISA KIT
ELI-50957m 96 Tests
EUR 1038

Human Protein capicua homolog, CIC ELISA KIT
ELI-10277h 96 Tests
EUR 988.8

Rat capicua homolog (Drosophila) (CIC) ELISA kit
E02C1725-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat capicua homolog (Drosophila) (CIC) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

 

 

 

An immunomodulatory molecule of symbiotic micro organism directs maturation of the host immune system.

 

The mammalian gastrointestinal tract harbors a fancy ecosystem consisting of numerous micro organism in homeostasis with the host immune system. Formed by evolution, this partnership has potential for symbiotic profit. Nevertheless, the identities of bacterial molecules mediating symbiosis stay undefined.
Right here we present that, throughout colonization of animals with the ever-present intestine microorganism Bacteroides fragilis, a bacterial polysaccharide (PSA) directs the mobile and bodily maturation of the creating immune system. Comparability with germ-free animals reveals that the immunomodulatory actions of PSA throughout B. fragilis colonization embody correcting systemic  ore intersting facts about the class is in Sainik school coaching in dehradun, T cell deficiencies and T(H)1/T(H)2 imbalances and directing lymphoid organogenesis.

Anti-CIC antibody

Description: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the excessive mobility group (HMG)-box superfamily of transcriptional repressors. This protein accommodates a conserved HMG area that’s concerned in DNA binding and nuclear localization, and a conserved C-terminus. Research recommend that the N-terminal area of this protein interacts with Atxn1 (GeneID:6310), to kind a transcription repressor advanced, and in vitro research recommend that polyglutamine-expansion of ATXN1 might alter the repressor exercise of this advanced.

Mutations on this gene have been related to olidogdendrogliomas (PMID:21817013). As well as, translocation occasions leading to gene fusions of this gene with each DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been related to spherical cell sarcomas. There are a number of pseudogenes of this gene discovered on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Various splicing leads to a number of transcript variants encoding completely different isoforms.
A PSA mutant of B. fragilis doesn’t restore these immunologic features. PSA introduced by intestinal dendritic cells prompts CD4+ T cells and elicits acceptable cytokine manufacturing. These findings present a molecular foundation for host-bacterial symbiosis and reveal the archetypal molecule of commensal micro organism that mediates growth of the host immune system.

Paradoxical roles of the immune system Throughout most cancers Improvement

 

The primary operate of the mammalian immune system is to observe tissue homeostasis, to guard in opposition to invading or infectious pathogens and to eradicate broken cells. Due to this fact, it’s stunning that most cancers happens with such a excessive frequency in people.

Human capicua homolog (Drosophila) (CIC) ELISA equipment

 

Current insights which have been gained from scientific research and experimental mouse fashions of carcinogenesis increase our understanding of the advanced relationship between immune cells and creating tumours. Right here, we look at the paradoxical function of adaptive and innate leukocytes as essential regulators of most cancers growth and spotlight latest insights which have been gained by manipulating immune responses in mouse fashions of de novo and spontaneous tumorigenesis.

 

 

 

IRG1 Recombinant Protein (Rat)
RP206252 100 ug Ask for price

IRG1 Recombinant Protein (Mouse)
RP144233 100 ug Ask for price

IRG1 Recombinant Protein (Human)
RP065916 100 ug Ask for price

Irg1 ORF Vector (Rat) (pORF)
ORF068752 1.0 ug DNA
EUR 607.2

IRG1 ORF Vector (Human) (pORF)
ORF021973 1.0 ug DNA Ask for price

Irg1 ORF Vector (Mouse) (pORF)
ORF048079 1.0 ug DNA
EUR 114

Irg1 sgRNA CRISPR Lentivector set (Rat)
K6650801 3 x 1.0 ug
EUR 406.8

IRG1 sgRNA CRISPR Lentivector set (Human)
K1099201 3 x 1.0 ug
EUR 406.8

Irg1 sgRNA CRISPR Lentivector set (Mouse)
K3063001 3 x 1.0 ug
EUR 406.8

Irg1 3'UTR GFP Stable Cell Line
TU160220 1.0 ml Ask for price

IRG1 3'UTR GFP Stable Cell Line
TU061267 1.0 ml
EUR 1672.8

Irg1 3'UTR GFP Stable Cell Line
TU256379 1.0 ml Ask for price

IRG1 Protein Vector (Rat) (pPM-C-HA)
PV275008 500 ng
EUR 723.6

IRG1 Protein Vector (Rat) (pPB-C-His)
PV275006 500 ng
EUR 723.6

IRG1 Protein Vector (Rat) (pPB-N-His)
PV275007 500 ng
EUR 723.6

IRG1 Protein Vector (Rat) (pPM-C-His)
PV275009 500 ng
EUR 723.6

IRG1 Protein Vector (Mouse) (pPM-C-HA)
PV192316 500 ng
EUR 723.6

IRG1 Protein Vector (Human) (pPM-C-HA)
PV087892 500 ng Ask for price

IRG1 Protein Vector (Mouse) (pPB-C-His)
PV192314 500 ng
EUR 723.6

IRG1 Protein Vector (Mouse) (pPB-N-His)
PV192315 500 ng
EUR 723.6

IRG1 Protein Vector (Mouse) (pPM-C-His)
PV192317 500 ng
EUR 723.6

IRG1 Protein Vector (Human) (pPB-C-His)
PV087890 500 ng Ask for price

IRG1 Protein Vector (Human) (pPB-N-His)
PV087891 500 ng Ask for price

IRG1 Protein Vector (Human) (pPM-C-His)
PV087893 500 ng Ask for price

Irg1 3'UTR Luciferase Stable Cell Line
TU110220 1.0 ml Ask for price

Irg1 3'UTR Luciferase Stable Cell Line
TU206379 1.0 ml Ask for price

IRG1 3'UTR Luciferase Stable Cell Line
TU011267 1.0 ml
EUR 1672.8

Irg1 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6650802 1.0 ug DNA
EUR 184.8

Irg1 sgRNA CRISPR Lentivector (Rat) (Target 2)
K6650803 1.0 ug DNA
EUR 184.8

Irg1 sgRNA CRISPR Lentivector (Rat) (Target 3)
K6650804 1.0 ug DNA
EUR 184.8

IRG1 sgRNA CRISPR Lentivector (Human) (Target 1)
K1099202 1.0 ug DNA
EUR 184.8

IRG1 sgRNA CRISPR Lentivector (Human) (Target 2)
K1099203 1.0 ug DNA
EUR 184.8

IRG1 sgRNA CRISPR Lentivector (Human) (Target 3)
K1099204 1.0 ug DNA
EUR 184.8

Irg1 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K3063002 1.0 ug DNA
EUR 184.8

Irg1 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K3063003 1.0 ug DNA
EUR 184.8

Irg1 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K3063004 1.0 ug DNA
EUR 184.8

Immune-Responsive Gene 1 Protein (IRG1) Antibody
20-abx216312
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

IRG1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)
LV622081 1.0 ug DNA
EUR 818.4

IRG1 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
LV622085 1.0 ug DNA
EUR 818.4

IRG1 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)
LV622086 1.0 ug DNA
EUR 818.4

Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
K6650805 3 x 1.0 ug
EUR 451.2

IRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K1099205 3 x 1.0 ug
EUR 451.2

Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K3063005 3 x 1.0 ug
EUR 451.2

Mouse IRG1 (Immune- responsive gene 1 protein) ELISA Kit (CUSTOM
ELI-08257m 96 Tests
EUR 1038

Human IRG1 (Immune- responsive gene 1 protein homolog) ELISA Kit
ELI-28070h 96 Tests
EUR 988.8

Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)
K6650806 1.0 ug DNA
EUR 200.4

Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)
K6650807 1.0 ug DNA
EUR 200.4

Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)
K6650808 1.0 ug DNA
EUR 200.4

IRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K1099206 1.0 ug DNA
EUR 200.4

IRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K1099207 1.0 ug DNA
EUR 200.4

IRG1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K1099208 1.0 ug DNA
EUR 200.4

Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K3063006 1.0 ug DNA
EUR 200.4

Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K3063007 1.0 ug DNA
EUR 200.4

Irg1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K3063008 1.0 ug DNA
EUR 200.4

IRG1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)
LV622082 1.0 ug DNA
EUR 818.4

IRG1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)
LV622083 1.0 ug DNA
EUR 888

IRG1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
LV622084 1.0 ug DNA
EUR 888

Irgc/ Rat Irgc ELISA Kit
ELI-43835r 96 Tests
EUR 1063.2

IRGC siRNA
20-abx920814
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

IRGC siRNA
20-abx920815
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

IRGM siRNA
20-abx920817
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

IRGM siRNA
20-abx920818
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

IRGQ siRNA
20-abx920819
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

IRGQ siRNA
20-abx920820
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

IRGM1 siRNA
20-abx920816
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

IRGM Rabbit pAb
A10968-100ul 100 ul
EUR 369.6

IRGM Rabbit pAb
A10968-200ul 200 ul
EUR 550.8

IRGM Rabbit pAb
A10968-20ul 20 ul Ask for price

IRGM Rabbit pAb
A10968-50ul 50 ul Ask for price

IRGC Peptide
5293P 0.05 mg
EUR 197.7
Description: (NT) IRGC peptide

IRGC Peptide
5295P 0.05 mg
EUR 197.7
Description: (CT) IRGC peptide

IRGM Peptide
4543P 0.05 mg
EUR 197.7
Description: (NT) IRGM peptide

IRGM Peptide
4545P 0.05 mg
EUR 197.7
Description: (IN) IRGM peptide

iRGD peptide
HY-P0122 5mg
EUR 555.6

IRGM Antibody
24660-100ul 100ul
EUR 468

IRGM Antibody
24661-100ul 100ul
EUR 468

IRGC Antibody
24944-100ul 100ul
EUR 468

IRGC Antibody
24945-100ul 100ul
EUR 468

IRGC Antibody
5295-002mg 0.02 mg
EUR 206.18
Description: IRGC Antibody: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.

IRGC Antibody
5295-01mg 0.1 mg
EUR 523.7
Description: IRGC Antibody: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.

IRGC antibody
70R-18012 50 ul
EUR 522
Description: Rabbit polyclonal IRGC antibody

IRGM Antibody
36558-100ul 100ul
EUR 302.4

IRGM Antibody
4543-002mg 0.02 mg
EUR 206.18
Description: IRGM Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa that also includes IRGM2 and IRGM3; this antibody may also recognize these proteins.

IRGM Antibody
4543-01mg 0.1 mg
EUR 523.7
Description: IRGM Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa that also includes IRGM2 and IRGM3; this antibody may also recognize these proteins.

IRGM Antibody
4545-002mg 0.02 mg
EUR 206.18
Description: IRGM Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa that also includes IRGM2 and IRGM3; this antibody may also recognize these proteins.

IRGM Antibody
4545-01mg 0.1 mg
EUR 523.7
Description: IRGM Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa that also includes IRGM2 and IRGM3; this antibody may also recognize these proteins.

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